ANTIBODIES TO PROGRAMMED CELL DEATH PROTEIN 1 THAT ARE PD-1 AGONISTS

Title:

ANTIBODIES TO PROGRAMMED CELL DEATH PROTEIN 1 THAT ARE PD-1 AGONISTS

Document Type and Number:

WIPO Patent Application WO/2023/147470

Kind Code:

A3

Abstract:

Antibodies and antigen-binding fragments thereof that immunospecifically bind to PD- 1, such as human or mouse PD-1, and are agonists of PD-1 and can induce or promote an immune response that activates immune cell proliferation or activity. Unlike the majority of known anti-PD-1 and anti-PD-Ll antibodies, which reduce the suppression of PD-1 function by e.g., PD-L1 by physically blocking the interaction between PD-1 and an inactivating ligand, although not to be bound by theory, the disclosed antibodies and antigen-binding fragments thereof are currently best understood to immunospecifically bind to an epitope of PD-1 whereby PD-1 is activated directly. Methods for the treatment of cancer comprising administration of the antibodies or antigen-binding fragments to a subject in need thereof. Polynucleotides encoding the antibodies or antigen-binding fragments. Host cells comprising the polynucleotides.

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Inventors:

MKRTICHYAN MIKAYEL (US)
KHLEIF SAMIR (US)

Application Number:

PCT/US2023/061449

Publication Date:

October 05, 2023

Filing Date:

January 27, 2023

Export Citation:

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Assignee:

GEORGIAMUNE INC (US)

International Classes:

C07K16/28; C07K16/30; A61K39/395; A61P35/00

Foreign References:

US20200317808A1	2020-10-08
US20060088883A1	2006-04-27
US20160032019A1	2016-02-04

Attorney, Agent or Firm:

UNDERWOOD, Robert, H. (US)

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