Title:
ANTIBODIES WITH ENHANCED OR SUPPRESSED EFFECTOR FUNCTION
Document Type and Number:
WIPO Patent Application WO/2011/120135
Kind Code:
A8
Abstract:
Rationally designed antibodies and polypeptides that comprise two Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides comprise Fc region mutations at two positions that synergistically make the polypeptides more effective when incorporated in antibody therapeutics than those having wild-type Fc components.
Inventors:
D ANGELO IGOR (CA)
BLEILE DUSTIN (CA)
TOM-YEW STACEY A L (CA)
ESCOBAR-CABRERA ERIC (CA)
LARIO PAULA I (CA)
OHRN ANDERS (CA)
POON DAVID K Y (CA)
DIXIT SURJIT B (CA)
BLEILE DUSTIN (CA)
TOM-YEW STACEY A L (CA)
ESCOBAR-CABRERA ERIC (CA)
LARIO PAULA I (CA)
OHRN ANDERS (CA)
POON DAVID K Y (CA)
DIXIT SURJIT B (CA)
Application Number:
PCT/CA2011/000322
Publication Date:
November 24, 2011
Filing Date:
March 28, 2011
Export Citation:
Assignee:
ZYMEWORKS INC (CA)
D ANGELO IGOR (CA)
BLEILE DUSTIN (CA)
TOM-YEW STACEY A L (CA)
ESCOBAR-CABRERA ERIC (CA)
LARIO PAULA I (CA)
OHRN ANDERS (CA)
POON DAVID K Y (CA)
DIXIT SURJIT B (CA)
D ANGELO IGOR (CA)
BLEILE DUSTIN (CA)
TOM-YEW STACEY A L (CA)
ESCOBAR-CABRERA ERIC (CA)
LARIO PAULA I (CA)
OHRN ANDERS (CA)
POON DAVID K Y (CA)
DIXIT SURJIT B (CA)
International Classes:
C07K16/00; A61K39/395; A61P35/00; A61P37/00; C07K14/735; C07K16/28; C07K19/00; C12N15/13; G16B15/30
Attorney, Agent or Firm:
SALISBURY, Clare et al. (2300 - 550 Burrard StreetVancouver, British Columbia, V6C 2B5, CA)
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