Title:
ANTIBODY AGAINST ALOPECIA-INDUCING SUBSTANCE AS ANTIGEN, COMPOSITION AND PRODUCTION METHOD
Document Type and Number:
WIPO Patent Application WO/2015/083375
Kind Code:
A1
Abstract:
Causes of hair loss have not been completely clarified but still remain unknown in many points. However, it appears that hair loss is partly caused by a mechanism wherein androgenic hormones in the scalp become active via the activation of DHT hormone by 5α-reductase and thus the activity of cells in hair roots is lost.
In the present invention, an antibody, said antibody being obtained by inoculating a female bird with 5α-reductase or DHT as an antigen, is administered to the scalp so that the activity of DHT is suppressed and the activity of cells in hair roots is elevated. This antibody can be used in the form of a composition together with other component(s), for example, as a hair tonic together with another hair growth promoter.
Inventors:
TSUKAMOTO YASUHIRO (JP)
Application Number:
PCT/JP2014/006028
Publication Date:
June 11, 2015
Filing Date:
December 02, 2014
Export Citation:
Assignee:
OSTRICH PHARMA KK (JP)
International Classes:
C07K16/02; A61K8/64; A61K8/98; A61K39/395; A61P17/14; A61Q7/00; C07K16/26; C07K16/40
Domestic Patent References:
| WO2008102783A1 | 2008-08-28 | |||
| WO2007026689A1 | 2007-03-08 |
Other References:
RANDAL V.A.: "Role of 5a-reductase in health and disease.", BAILLIERES CLIN. ENDOCRINOL. METAB., vol. 8, no. 2, 1994, pages 405 - 431
BAYNE E.K. ET AL.: "Immunohistochemical localization of types 1 and 2 5alpha-reductase in human scalp.", BR. J. DERMATOL., vol. 141, no. 3, 1999, pages 481 - 491
BAYNE E.K. ET AL.: "Immunohistochemical localization of types 1 and 2 5alpha-reductase in human scalp.", BR. J. DERMATOL., vol. 141, no. 3, 1999, pages 481 - 491
Attorney, Agent or Firm:
HIROKOH, MASAKI (JP)
Hiroyuki Masaki (JP)
Hiroyuki Masaki (JP)
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