Title:
ANTIBODY AGAINST MUC1 OR ANTIGEN-BINDING FRAGMENT THEREOF, GENE ENCODING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/077951
Kind Code:
A1
Abstract:
Provided is a novel antibody against MUC1 or an antigen-binding fragment thereof. The antibody according to the present invention or an antigen-binding fragment thereof contains heavy chain variable regions and light chain variable regions, wherein: the heavy chain variable regions comprise an amino acid sequence of SEQ ID NO:1 or a heavy chain CDR1, a heavy chain CDR2 and a heavy chain CDR3, wherein the heavy chain CDR1, heavy chain CDR2 and heavy chain CDR3 are polypeptides respectively containing amino acid sequences of (H1-1) of SEQ ID NO: 2, (H2-1) of SEQ ID NO: 3 and (H3-1) of SEQ ID NO: 4; and the light chain variable regions comprise an amino acid sequence of SEQ ID NO: 5 or a light chain CDR1, a light chain CDR2 and a light chain CDR3, wherein the light chains CDR1, CDR2 and CDR3 are polypeptides respectively containing amino acid sequences of (L1-1) of SEQ ID NO: 6, (L2-2) of SEQ ID NO: 7 and (L3-3) of SEQ ID NO: 8.
Inventors:
KURODA MASAHIKO (JP)
OHNO SHIN-ICHIRO (JP)
FUJITA KOJI (JP)
HARADA YUICHIROU (JP)
OHNO SHIN-ICHIRO (JP)
FUJITA KOJI (JP)
HARADA YUICHIROU (JP)
Application Number:
PCT/JP2018/035631
Publication Date:
April 25, 2019
Filing Date:
September 26, 2018
Export Citation:
Assignee:
UNIV TOKYO MEDICAL (JP)
International Classes:
C12N15/13; C07K16/18; C12N15/63; G01N33/574; C12P21/08
Domestic Patent References:
| WO2013185552A1 | 2013-12-19 | |||
| WO2017061152A1 | 2017-04-13 | |||
| WO2011135869A1 | 2011-11-03 |
Foreign References:
| JPH07505775A | 1995-06-29 |
Other References:
MOVAHEDIN, M. ET AL.: "Glycosylation of MUC1 influences the binding of a therapeutic antibody by altering the conformational equilibrium of the antigen", GLYCOBIOLOGY, vol. 27, no. 7, 25 January 2017 (2017-01-25) - 1 July 2017 (2017-07-01), pages 677 - 687, XP055597996, ISSN: 0959-6658, DOI: 10.1093/glycob/cww131
DANIELCZYK, A. ET AL.: "PankoMab: a potent new generation anti-tumour MUC1 antibody", CANCER IMMUNOL. IMMUNOTHER., vol. 55, no. 11, 2006, pages 1337 - 1347, XP019422497, ISSN: 0340-7004, DOI: doi:10.1007/s00262-006-0135-9
DANIELCZYK, A. ET AL.: "PankoMab: a potent new generation anti-tumour MUC1 antibody", CANCER IMMUNOL. IMMUNOTHER., vol. 55, no. 11, 2006, pages 1337 - 1347, XP019422497, ISSN: 0340-7004, DOI: doi:10.1007/s00262-006-0135-9
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
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