Title:
ANTIBODY-BASED MOLECULES SPECIFIC FOR THE TRUNCATED ASP421 EPITOPE OF TAU AND THEIR USES IN THE DIAGNOSIS AND TREATMENT OF TAUOPATHY
Document Type and Number:
WIPO Patent Application WO/2017/027685
Kind Code:
A3
Abstract:
The present invention relates to antibody-based molecules (including single domain antibody fragment, scFv molecules, antibodies, antibody fragments, diabodies, and the epitope-binding domains thereof) that are capable of immunospecifically and selectively binding to the truncated Asp421 epitope of Tau. Such antibody -based molecules are useful to detect pathological Tau protein conformer if present in a biological sample, especially in conjunction with the diagnosis and/or treatment of Alzheimer's disease or other tauopathy, and thus provide a diagnostic for Alzheimer's disease and other Tau pathologies. The antibody-based molecules of the present invention have particular utility as diagnostic markers for, Alzheimer's disease and related tauopathies and as pharmaceutical compositions for the treatment of such conditions.
Inventors:
SIGURDSSON EINAR (US)
Application Number:
PCT/US2016/046513
Publication Date:
March 23, 2017
Filing Date:
August 11, 2016
Export Citation:
Assignee:
UNIV NEW YORK (US)
International Classes:
A61K39/00; A61K39/395; A61K51/10; A61P25/00; A61P25/28; C07K16/18
Foreign References:
| US20100316564A1 | 2010-12-16 | |||
| US20090317805A1 | 2009-12-24 | |||
| US20050266003A1 | 2005-12-01 | |||
| US20050255102A1 | 2005-11-17 | |||
| US20130058960A1 | 2013-03-07 | |||
| US20150118184A1 | 2015-04-30 | |||
| US20120244146A1 | 2012-09-27 |
Other References:
See also references of EP 3334453A4
Attorney, Agent or Firm:
AUERBACH, Jeffrey, I. et al. (US)
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