Title:
ANTIBODY-BINDING PEPTIDE-FERRITIN FUSION PROTEIN AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/055058
Kind Code:
A2
Abstract:
The present invention relates to nanoparticles including 24 antibody-binding peptide-ferritin fusion protein monomers, the nanoparticles being characterized in that six partial structures having a 4-fold symmetry point are formed due to ferritin, and an antibody-binding peptide is fused to the ferritin in a range of ±10 a.a. of the 4-fold symmetry point such that 4 antibody-binding peptides are positioned in the vicinity of the 4-fold symmetry point; and also relates to uses of the nanoparticles. The present invention can be used for biochips, drug delivery systems, disorder diagnosis, and the development of treating agents by producing the fusion protein through the introduction of the sequence of the antibody-binding peptide into the ferritin, and using the fusion protein to allow the antibody to strongly bind to the ferritin without any damage to the antibody structure.
Inventors:
CHUNG SANG JEON (KR)
KANG SE BYUNG (KR)
KANG HYO JIN (KR)
KANG YOUNG JI (KR)
LEE YOUNG MI (KR)
KANG SE BYUNG (KR)
KANG HYO JIN (KR)
KANG YOUNG JI (KR)
LEE YOUNG MI (KR)
Application Number:
PCT/KR2012/007993
Publication Date:
April 18, 2013
Filing Date:
October 02, 2012
Export Citation:
Assignee:
KOREA RES INST OF BIOSCIENCE (KR)
UNIST ACADEMY IND RES CORP (KR)
UNIST ACADEMY IND RES CORP (KR)
International Classes:
A61K38/00; A61K9/16; A61K39/395; A61K47/48
Foreign References:
| US20090035389A1 | 2009-02-05 | |||
| KR100953917B1 | 2010-04-22 |
Other References:
JAASKELAINEN, A. ET AL.: 'Development of a Denaturation/Renaturation-Based Production Process for Ferritin Nanoparticles.' BIOTECHNOLOGY AND BIOENGINEERING. vol. 102, no. 4, 2009, pages 1012 - 1024
LI, C. Q. ET AL.: 'Ferritin nanoparticle technology: a new platform for antigen presentation and vaccine development.' INDUSTRIAL BIOTECHNOLOGY. vol. 2, no. 2, 2006, pages 143 - 147
UCHIDA, M. ET AL.: 'Targeting of Cancer Cells with Ferrimagnetic Ferritin Cage Nanoparticles.' JOURNAL OF AMERICAN CHEMICAL SOCIETY vol. 128, 2006, pages 16626 - 16633
LI, C. Q. ET AL.: 'Ferritin nanoparticle technology: a new platform for antigen presentation and vaccine development.' INDUSTRIAL BIOTECHNOLOGY. vol. 2, no. 2, 2006, pages 143 - 147
UCHIDA, M. ET AL.: 'Targeting of Cancer Cells with Ferrimagnetic Ferritin Cage Nanoparticles.' JOURNAL OF AMERICAN CHEMICAL SOCIETY vol. 128, 2006, pages 16626 - 16633
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
손민 (KR)
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