Title:
ANTIBODY BINDING TO HEPATITIS B VIRUS SURFACE ANTIGEN AND APPLICATION OF ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2022/007955
Kind Code:
A1
Abstract:
Provided are an antibody or antigen-binding fragment thereof that specifically binds to hepatitis B virus surface antigen (HBsAg), a pharmaceutical composition containing the antibody or antigen-binding fragment, and use thereof. Further provided are a nucleic acid molecule encoding the antibody, a vector and a host cell containing the nucleic acid molecule, and a method for preparing the antibody.
Inventors:
XU ZHENG (CN)
CHANG HONGYAN (CN)
LI XIANG (CN)
SONG RUI (CN)
LIU YING (CN)
LI FENG (CN)
CHANG HONGYAN (CN)
LI XIANG (CN)
SONG RUI (CN)
LIU YING (CN)
LI FENG (CN)
Application Number:
PCT/CN2021/105523
Publication Date:
January 13, 2022
Filing Date:
July 09, 2021
Export Citation:
Assignee:
BEIJING KAWIN TECH SHARE HOLDING CO LTD (CN)
International Classes:
C07K16/08; A61K39/395; A61P31/20; C07K16/00; C12N15/13
Domestic Patent References:
| WO2019229699A1 | 2019-12-05 | |||
| WO2019006162A1 | 2019-01-03 | |||
| WO1993011161A1 | 1993-06-10 |
Foreign References:
| CN103533929A | 2014-01-22 | |||
| CN110105451A | 2019-08-09 | |||
| EP0404097A2 | 1990-12-27 | |||
| US5641870A | 1997-06-24 | |||
| US8602269W | 1986-10-27 | |||
| EP0173494A2 | 1986-03-05 | |||
| US5585089A | 1996-12-17 |
Other References:
KEUN-SOO KIM, HYUN-JUNG KIM, BYUNG WOO HAN, PYUNG-KEUN MYUNG, HYO JEONG HONG: "Construction of a humanized antibody to hepatitis B surface antigen by specificity-determining residues (SDR)-grafting and de-immunization", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 396, no. 2, 1 May 2010 (2010-05-01), Amsterdam NL , pages 231 - 237, XP055590335, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2010.04.071
ZHOU BING; XIA LIN; ZHANG TIANYING; YOU MIN; HUANG YANG; HE MAOZHOU; SU RUOPENG; TANG JIXIAN; ZHANG JUAN; LI SHAOWEI; AN ZHIQIANG;: "Structure guided maturation of a novel humanized anti-HBV antibody and its preclinical development", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 180, 12 March 2020 (2020-03-12), NL , XP086226152, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2020.104757
GUO YU, LIANG MI-FANG, BI SHENG-LI: "Development of Recombinant Human-Derived IgG Antibody Against HBsAg", CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY, vol. 18, no. 2, 30 June 2004 (2004-06-30), XP055885598
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PNAS (USA, vol. 85, 1988, pages 5879 - 5883
HOLLINGER ET AL., PR°C. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ZAPATA ET AL., PROTEIN ENG, vol. 8, no. 10, 1995, pages 1057 - 1062
LEFRANC M.P.: "The IMGT unique numbering for immunoglobulins, T-cell receptors, and Ig-like domains", THE IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", vol. 1-3, 1991
WU ET AL., J. BIOL. CHEM., vol. 262, 1987, pages 4429 - 4432
LANGER, SCIENCE, vol. 249, 1990, pages 1527 - 1533
TREAT ET AL.: "Liposomes in the Therapy of Infectious Disease and Cancer", 1989, LISS, pages: 353 - 365
SEFTON, CRC CRIT. REF. BIOMED. ENG, vol. 14, no. 201, 1987
"Medical Applications of Controlled Release", 1974, CRC PRESS
See also references of EP 4180456A4
ZHOU BING; XIA LIN; ZHANG TIANYING; YOU MIN; HUANG YANG; HE MAOZHOU; SU RUOPENG; TANG JIXIAN; ZHANG JUAN; LI SHAOWEI; AN ZHIQIANG;: "Structure guided maturation of a novel humanized anti-HBV antibody and its preclinical development", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 180, 12 March 2020 (2020-03-12), NL , XP086226152, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2020.104757
GUO YU, LIANG MI-FANG, BI SHENG-LI: "Development of Recombinant Human-Derived IgG Antibody Against HBsAg", CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY, vol. 18, no. 2, 30 June 2004 (2004-06-30), XP055885598
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PNAS (USA, vol. 85, 1988, pages 5879 - 5883
HOLLINGER ET AL., PR°C. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ZAPATA ET AL., PROTEIN ENG, vol. 8, no. 10, 1995, pages 1057 - 1062
LEFRANC M.P.: "The IMGT unique numbering for immunoglobulins, T-cell receptors, and Ig-like domains", THE IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", vol. 1-3, 1991
WU ET AL., J. BIOL. CHEM., vol. 262, 1987, pages 4429 - 4432
LANGER, SCIENCE, vol. 249, 1990, pages 1527 - 1533
TREAT ET AL.: "Liposomes in the Therapy of Infectious Disease and Cancer", 1989, LISS, pages: 353 - 365
SEFTON, CRC CRIT. REF. BIOMED. ENG, vol. 14, no. 201, 1987
"Medical Applications of Controlled Release", 1974, CRC PRESS
See also references of EP 4180456A4
Attorney, Agent or Firm:
BEIJING CAI HE LAW FIRM (CN)
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