Title:
ANTIBODY CAPABLE OF BINDING TO TRANSFORMING GROWTH FACTOR ALPHA AND HAVING ANTIPROLIFERATIVE ACTIVITY ON CANCER HAVING Ras GENE MUTATION
Document Type and Number:
WIPO Patent Application WO/2011/145629
Kind Code:
A2
Abstract:
Among antibodies exhibiting reactivity to natural TGFα, antibodies having low reactivity to G79A-substituted TGFα are identified as exhibiting superior antiproliferative activity against cancer cells having a mutation in the Ras gene. Further identified is that many of the antibodies also inhibit the tyrosine phosphorylation of EGFR and/or inhibit the induction of vascular endothelial cells.
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Inventors:
KANEDA MAKOTO (JP)
FUJII YOSHIHIRO (JP)
HAYATA YOSHIHIRO (JP)
KISHI YOSHIRO (JP)
YAHARA ICHIRO (JP)
FUJII YOSHIHIRO (JP)
HAYATA YOSHIHIRO (JP)
KISHI YOSHIRO (JP)
YAHARA ICHIRO (JP)
Application Number:
PCT/JP2011/061347
Publication Date:
November 24, 2011
Filing Date:
May 17, 2011
Export Citation:
Assignee:
MED & BIOLOGICAL LAB CO LTD (JP)
KANEDA MAKOTO (JP)
FUJII YOSHIHIRO (JP)
HAYATA YOSHIHIRO (JP)
KISHI YOSHIRO (JP)
YAHARA ICHIRO (JP)
KANEDA MAKOTO (JP)
FUJII YOSHIHIRO (JP)
HAYATA YOSHIHIRO (JP)
KISHI YOSHIRO (JP)
YAHARA ICHIRO (JP)
International Classes:
C12N15/09; A61K39/395; A61P35/00; C07K14/495; C07K16/24; C07K16/42; C12N5/10; C12N15/02; C12P21/08; G01N33/574
Other References:
See references of EP 2573175A4
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
Patent business corporation cent Crest international patent firm (JP)
Patent business corporation cent Crest international patent firm (JP)
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Claims:
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