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Title:
ANTIBODY CAPABLE OF SPECIFICALLY RECOGNIZING TRANSFERRIN RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2014/073641
Kind Code:
A1
Abstract:
The present invention provides an antibody wherein a first heavy chain complementarity determining region (VH CDR1), a second heavy chain complementarity determining region (VH CDR2), and a third heavy chain complementarity determining region (VH CDR3) are SEQ ID NOs: 1, 2 and 7, respectively, and a first light chain complementarity determining region (VL CDR1), a second light chain complementarity determining region (VL CDR2), and a third light chain complementarity determining region (VL CDR3) are SEQ ID NOs: 4, 5 and 6, respectively.

Inventors:
KUROSAWA YOSHIKAZU (JP)
MORISHITA KAZUHIRO (JP)
ZHANG LILIN (JP)
KUROSAWA GENE (JP)
MITOMO KATSUYUKI (JP)
SUDO YUKIO (JP)
NOMURA FUMIKO (JP)
UKAI YOSHINORI (JP)
Application Number:
PCT/JP2013/080249
Publication Date:
May 15, 2014
Filing Date:
November 08, 2013
Export Citation:
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Assignee:
UNIV MIYAZAKI (JP)
PERSEUS PROTEOMICS INC (JP)
International Classes:
C07K16/28; A61K39/395; A61P35/00; A61P35/02; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/08
Domestic Patent References:
WO2011073943A12011-06-23
WO2008007648A12008-01-17
WO2006090750A12006-08-31
WO2012153707A12012-11-15
WO2013031619A12013-03-07
WO1993012227A11993-06-24
WO1992003918A11992-03-19
WO1994002602A11994-02-03
WO1994025585A11994-11-10
WO1996034096A11996-10-31
WO1996033735A11996-10-31
WO1992001047A11992-01-23
WO1992020791A11992-11-26
WO1993006213A11993-04-01
WO1993011236A11993-06-10
WO1993019172A11993-09-30
WO1995014388A11995-06-01
WO2011073943A12011-06-23
WO2012153707A12012-11-15
WO1992002190A11992-02-20
WO1992001047A11992-01-23
WO1992020791A11992-11-26
WO1993006213A11993-04-01
WO1993011236A11993-06-10
WO1993019172A11993-09-30
WO1995001438A11995-01-12
WO1995015388A11995-06-08
WO1997010354A11997-03-20
WO2008007648A12008-01-17
Foreign References:
CN101245107A2008-08-20
JP2005185281A2005-07-14
JP2013194043A2013-09-30
US5667781A1997-09-16
US7976841B22011-07-12
EP0120694A21984-10-03
EP0125023A11984-11-14
GB2188638A1987-10-07
US5585089A1996-12-17
JP4870348B22012-02-08
US5530101A1996-06-25
US5693761A1997-12-02
US5693792A1997-12-02
US5714350A1998-02-03
US5777085A1998-07-07
JP2008516896A2008-05-22
Other References:
POUL M.-A. ET AL.: "Selection of Tumor-Specific Internalizing Human Antibodies from Phage Libraries", J. MOL. BIOL., vol. 301, 2000, pages 1149 - 1161, XP008153825
GAO C. ET AL.: "De novo identification of tumor- specific internalizing human antibody-receptor pairs by phage-display methods", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 274, 2003, pages 185 - 197, XP004411948
MASS R ET AL., PROC AM SOCI CLIN ONCOL, vol. 19, 2000, pages 75A
BERINSTEIN NL ET AL.: "Annals of Oncology", vol. 9, 1998, pages: 995 - 1001
BRUGGEMANNM. ET AL., J. EXP. MED, vol. 166, pages 1351 - 1361
LOOS M., PROG. ALLERGY, vol. 30, 1982, pages 135 - 192
MOL IMMUNOL., vol. 19, no. 5, May 1982 (1982-05-01), pages 651 - 7
J CLIN INVEST, vol. 42, 1963, pages 314 - 326
INT J CANCER, vol. 27, 1981, pages 329 - 334
J UROL, vol. 143, 1990, pages 381 - 385
CANCER GENE THER, vol. 7, 2000, pages 59 - 65
EUR J CANCER, vol. 40, no. 9, 2004, pages 1418 - 1422
J CLIN INVEST, vol. 65, 1980, pages 1182 - 1191
PLACENTA, vol. 7, 1986, pages 391 - 403
J CLIN INVEST, vol. 66, 1980, pages 1135 - 1143.10
PROC. NATL ACAD SCI USA, vol. 79, 1982, pages 1175 - 1179
CANCER RES, vol. 46, 1986, pages 1759 - 1763
CANCER RES, vol. 50, 1990, pages 6295 - 6301
BLOOD, vol. 103, 2004, pages 1838 - 1845
J. CLIN. ONCOL., vol. 2, 1984, pages 881
BLOOD, vol. 65, 1985, pages 1349
J. NATL. CANCER INST., vol. 80, 1988, pages 932
PROC. NATL. ACAD. SCI., vol. 82, 1985, pages 1242
J. NUCL. MED., vol. 26, 1985, pages 1011
J. NATL. CANCER INST., vol. 80, 1988, pages 937
J. IMMUNOL., vol. 135, 1985, pages 1530
CANCER RES., vol. 46, 1986, pages 6489
CLINI. CANCER. RES., vol. 1, 1995, pages 1259 - 1265
J. EXP. MED., vol. 170, 1989, pages 2153 - 2157
NATURE, vol. 332, 1988, pages 323 - 327
CANCER RES., vol. 61, 2001, pages 6851 - 6859
JPHARMBIOMEDANAL., vol. 41, 2006, pages 1347 - 1353
INT J ONCOL., vol. 13, no. 4, 1998, pages 871 - 5
TOHOKU J. EXP. MED., vol. 153, 1987, pages 239 - 243
UROL. RES., vol. 15, 1987, pages 341 - 344
BR. J. UROL., vol. 65, 1990, pages 339 - 344
HISTOPATHOLOGY, vol. 12, 1988, pages 53 - 63
J. CLIN. PATHOL., vol. 37, 1984, pages 131 - 135
APATHOL. ANAT. HISTOPATHOL., vol. 416, 1990, pages 491 - 496
LEUKEMIA, vol. 7, 1993, pages 2019 - 2025
HEMATOL. PATHOL., vol. 4, 1990, pages 37 - 41
LANCET, vol. 1, 1983, pages 498 - 501
WINTER ET AL., IMMUNOL. TODAY, vol. 14, 1993, pages 43 - 46
HASHIMOTO-GOTOH, T; MIZUNO, T; OGASAHARA, Y; KAGAWA, M.: "An oligodeoxyribonucleotide-directed dual amber method for site-directed mutagenesis", GENE, vol. 152, 1995, pages 271 - 275, XP004042690, DOI: doi:10.1016/0378-1119(94)00750-M
ZOLLER, MJ; SMITH, M.: "Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors", METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500, XP001088749, DOI: doi:10.1016/0076-6879(83)00074-9
KRAMER, W; DRUTSA, V; JANSEN, HW; KRAMER, B; PFLUGFELDER, M; FRITZ, HJ: "The gapped duplex DNA approach to oligonucleotide-directed mutation construction", NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456, XP002026371
KRAMER W; FRITZ HJ: "Oligonucleotide-directed construction of mutations via gapped duplex DNA Methods", ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA: "Rapid and efficient site-specific mutagenesis without phenotypic selection", PROC NATL ACAD SCI USA., vol. 82, 1985, pages 488 - 492, XP002052322, DOI: doi:10.1073/pnas.82.2.488
ZOLLER, MJ; SMITH, M: "Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors", METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500, XP001088749, DOI: doi:10.1016/0076-6879(83)00074-9
KRAMER, W; DRUTSA, V; JANSEN, H W; KRAMER, B; PFLUGFELDER, M; FRITZ, HJ: "The gapped duplex DNA approach to oligonucleotide-directed mutation construction", NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456, XP002026371
KRAMER W; FRITZ HJ: "Oligonucleotide-directed construction of mutations via gapped duplex DNA Methods", ENZYMOL, vol. 154, 1987, pages 350 - 367
KABAT, E. A. ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NIH PUBLICATION NO. 91-3242
A. WRIGHT; S. L. MORRISON, J. IMMUNOL., vol. 160, 1998, pages 3393 - 3402
K. MOTMANS ET AL., EUR. J. CANCER PREV., vol. 5, 1996, pages 512 - 5199
R P. JUNGHANS ET AL., CANCER RES., vol. 50, 1990, pages 1495 - 1502
R. W. MALONE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 6007
P. L. FELGNER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 84, pages 7413
F. L. GRAHAM; A. J. VAN DER EB, VIROLOGY, vol. 52, 1973, pages 456 - 467
CLIN CANCER RES., vol. 10, no. 13, 1 July 2004 (2004-07-01), pages 4538 - 49
CANCER RESEARCH, vol. 68, no. 22, 2008, pages 9280
NATURE BIOTECHNOLOGY, vol. 26, no. 8, 2008, pages 925
BIO CONJUGATE CHEMISTRY, vol. 19, 2008, pages 1673
CANCER RESEARCH, vol. 68, no. 15, 2008, pages 6300
BIOCONJUG CHEM., vol. 5, no. 2, March 1994 (1994-03-01), pages 101 - 4
BIOCONJUG CHEM., vol. 9, no. 6, November 1998 (1998-11-01), pages 773 - 82
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
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