Title:
ANTIBODY COMBINATION AND SYSTEM FOR DETECTING PROGNOSIS OF NASOPHARYNGEAL CANCER, AND USE
Document Type and Number:
WIPO Patent Application WO/2024/060326
Kind Code:
A1
Abstract:
Provided is an antibody combination for detecting the prognosis of nasopharyngeal cancer. The antibody combination comprises at least one of IGHM, IGHD, IGHA1, IGHA2, IGHG1, IGHG2, IGHG3, and IGHG4. Provided are use of the antibody combination and a system for predicting the prognosis of nasopharyngeal cancer. By determining the expression levels of heavy chains of the antibody combination, clinical prognosis prediction can be carried out on a patient with nasopharyngeal cancer, which facilitates the implementation of individualized treatment and the improvement of a survival benefit.
Inventors:
BEI JINXIN (CN)
LIU YANG (CN)
HE SHUAI (CN)
LIU YANG (CN)
HE SHUAI (CN)
Application Number:
PCT/CN2022/124075
Publication Date:
March 28, 2024
Filing Date:
October 09, 2022
Export Citation:
Assignee:
SUN YAT SEN UNIV CANCER CENTER THE AFFILIATED CANCER HOSPITAL OF SUN YAT SEN UNIV SUN YAT SEN UNIV C (CN)
International Classes:
C12Q1/68; G01N33/574; G01N33/68
Domestic Patent References:
| WO2011133770A2 | 2011-10-27 |
Foreign References:
| CN110687283A | 2020-01-14 | |||
| CN101238224A | 2008-08-06 | |||
| CN101063683A | 2007-10-31 | |||
| CN106706921A | 2017-05-24 |
Other References:
GONG LANQI, KWONG DORA LAI-WAN, DAI WEI, WU PINGAN, LI SHANSHAN, YAN QIAN, ZHANG YU, ZHANG BAIFENG, FANG XIAONA, LIU LI, LUO MIN, : "Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 12, no. 1, 1 January 2021 (2021-01-01), UK, pages 1540, XP093148767, ISSN: 2041-1723, DOI: 10.1038/s41467-021-21795-z
ZOU,Z.N. ET AL.: "Identification of tumor-infiltrating immune cells and microenvironment-relevant genes in nasopharyngeal carcinoma based on gene expression profiling", LIFE SCIENCES, vol. 263, 20 October 2020 (2020-10-20), XP086389309, DOI: 10.1016/j.lfs.2020.118620
XU SHENG-EN, WEI XU;FEI-PENG ZHAO; JIN-LIANG YANG; CHUAN-YU LIANG: "Expression of IgM and its significance in human nasopharyngeal carcinoma tissues", CHINA JOURNAL OF MODERN MEDICINE, ZHONGNAN DAXUE, CN, vol. 27, no. 29, 8 December 2017 (2017-12-08), CN , pages 25 - 31, XP093148773, ISSN: 1005-8982, DOI: 10.3969/j.issn.1005-8982.2017.29.006
CAI XIN‐ZHANG, ZENG WEI‐QUN, XIANG YI, LIU YI, ZHANG HONG‐MIN, LI HONG, SHE SHA, YANG MIN, XIA KUN, PENG SHI‐FANG: "iTRAQ‐Based Quantitative Proteomic Analysis of Nasopharyngeal Carcinoma", JOURNAL OF CELLULAR BIOCHEMISTRY, JOHN WILEY & SONS, INC. JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 116, no. 7, 1 July 2015 (2015-07-01), Hoboken, USA, pages 1431 - 1441, XP093148775, ISSN: 0730-2312, DOI: 10.1002/jcb.25105
FENG, X.S. ET AL.: "ITRAQ-Coupled 2-D LC-MS/MS Analysis of Differentially Expressed Serum Proteins in Nasopharyngeal Carcinoma Clinical Samples: Potential in Biomarker Discovery", JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS, vol. 1, no. 2, 31 December 2011 (2011-12-31)
周毅波 (ZHOU, YIBO): "鼻咽癌免疫编辑相关基因及免疫相关染色体异常区域初步筛选 (Preliminary Screening of Immunoediting Related Genes and Immuno-related Abnormal Chromosome Regions in Nasopharyngeal Carcinoma)", 中国优秀硕士学位论文全文数据库, 医药卫生科技辑 (MEDICAL AND HEALTH SCIENCES, CHINA MASTER’S THESES FULL-TEXT DATABASE), 15 January 2009 (2009-01-15)
张改霞 (ZHANG, GAIXIA): "鼻咽癌血清免疫球蛋白及轻链检测价值分析 (Non-official translation: Analysis of the Value of Serum Immunoglobulin and Light Chain Testing for Nasopharyngeal Carcinoma)", 中国实用医药 (CHINA PRACTICAL MEDICINE), vol. 14, no. 36, 31 December 2019 (2019-12-31)
LIU, Y. ET AL.: "Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution", NATURE COMMUNICATIONS, vol. 12, 2 February 2021 (2021-02-02), XP093133781, DOI: 10.1038/s41467-021-21043-4
ZOU,Z.N. ET AL.: "Identification of tumor-infiltrating immune cells and microenvironment-relevant genes in nasopharyngeal carcinoma based on gene expression profiling", LIFE SCIENCES, vol. 263, 20 October 2020 (2020-10-20), XP086389309, DOI: 10.1016/j.lfs.2020.118620
XU SHENG-EN, WEI XU;FEI-PENG ZHAO; JIN-LIANG YANG; CHUAN-YU LIANG: "Expression of IgM and its significance in human nasopharyngeal carcinoma tissues", CHINA JOURNAL OF MODERN MEDICINE, ZHONGNAN DAXUE, CN, vol. 27, no. 29, 8 December 2017 (2017-12-08), CN , pages 25 - 31, XP093148773, ISSN: 1005-8982, DOI: 10.3969/j.issn.1005-8982.2017.29.006
CAI XIN‐ZHANG, ZENG WEI‐QUN, XIANG YI, LIU YI, ZHANG HONG‐MIN, LI HONG, SHE SHA, YANG MIN, XIA KUN, PENG SHI‐FANG: "iTRAQ‐Based Quantitative Proteomic Analysis of Nasopharyngeal Carcinoma", JOURNAL OF CELLULAR BIOCHEMISTRY, JOHN WILEY & SONS, INC. JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 116, no. 7, 1 July 2015 (2015-07-01), Hoboken, USA, pages 1431 - 1441, XP093148775, ISSN: 0730-2312, DOI: 10.1002/jcb.25105
FENG, X.S. ET AL.: "ITRAQ-Coupled 2-D LC-MS/MS Analysis of Differentially Expressed Serum Proteins in Nasopharyngeal Carcinoma Clinical Samples: Potential in Biomarker Discovery", JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS, vol. 1, no. 2, 31 December 2011 (2011-12-31)
周毅波 (ZHOU, YIBO): "鼻咽癌免疫编辑相关基因及免疫相关染色体异常区域初步筛选 (Preliminary Screening of Immunoediting Related Genes and Immuno-related Abnormal Chromosome Regions in Nasopharyngeal Carcinoma)", 中国优秀硕士学位论文全文数据库, 医药卫生科技辑 (MEDICAL AND HEALTH SCIENCES, CHINA MASTER’S THESES FULL-TEXT DATABASE), 15 January 2009 (2009-01-15)
张改霞 (ZHANG, GAIXIA): "鼻咽癌血清免疫球蛋白及轻链检测价值分析 (Non-official translation: Analysis of the Value of Serum Immunoglobulin and Light Chain Testing for Nasopharyngeal Carcinoma)", 中国实用医药 (CHINA PRACTICAL MEDICINE), vol. 14, no. 36, 31 December 2019 (2019-12-31)
LIU, Y. ET AL.: "Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution", NATURE COMMUNICATIONS, vol. 12, 2 February 2021 (2021-02-02), XP093133781, DOI: 10.1038/s41467-021-21043-4
Attorney, Agent or Firm:
GUANGZHOU SINO PATENT & TRADEMARK AGENT CO., LTD. (CN)
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