Title:
ANTIBODY AND ANTIBODY COMPOSITION PRODUCTION METHOD
Document Type and Number:
WIPO Patent Application WO/2014/069647
Kind Code:
A1
Abstract:
[Problem] To provide: an antibody comprising at least two kinds of Fab, and in particular having restricted light chain-heavy chain combinations; a corresponding antibody composition; and production methods for same. [Solution] The present invention provides production methods for (1) an antibody or (2) an antibody composition, the methods using non-natural disulfide bonds.
Inventors:
ENAMI JUMPEI (JP)
SASAKI TETSUO (JP)
SUZUKI HIROKAZU (JP)
SASAKI TETSUO (JP)
SUZUKI HIROKAZU (JP)
Application Number:
PCT/JP2013/079797
Publication Date:
May 08, 2014
Filing Date:
November 01, 2013
Export Citation:
Assignee:
ZENYAKU KOGYO KK (JP)
International Classes:
C07K16/28; C12P21/08; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09
Domestic Patent References:
| WO2006106905A1 | 2006-10-12 | |||
| WO2012025530A1 | 2012-03-01 | |||
| WO2004111233A1 | 2004-12-23 | |||
| WO1998050431A2 | 1998-11-12 | |||
| WO2010151792A1 | 2010-12-29 | |||
| WO2009089004A1 | 2009-07-16 | |||
| WO2007147901A1 | 2007-12-27 | |||
| WO2011034605A2 | 2011-03-24 | |||
| WO2000061739A1 | 2000-10-19 | |||
| WO1993006213A1 | 1993-04-01 | |||
| WO1993008829A1 | 1993-05-13 | |||
| WO1994004690A1 | 1994-03-03 | |||
| WO2009080251A1 | 2009-07-02 | |||
| WO1990013646A1 | 1990-11-15 | |||
| WO1994011026A2 | 1994-05-26 |
Foreign References:
| JP2011505848A | 2011-03-03 | |||
| JP2011506509A | 2011-03-03 | |||
| JP2006515503A | 2006-06-01 | |||
| JPH09502862A | 1997-03-25 | |||
| US7183076B2 | 2007-02-27 | |||
| US20050054832A1 | 2005-03-10 | |||
| US6075181A | 2000-06-13 | |||
| US6150584A | 2000-11-21 | |||
| JP4324231B2 | 2009-09-02 |
Other References:
SCHMIEDL, A. ET AL.: "Expression of a bispecific dsFv-dsFv' antibody fragment in Escherichia coli.", PROTEIN ENGINEERING, vol. 13, no. 10, 2000, pages 725 - 734, XP055261340
See also references of EP 2915819A4
WRIGHT ET AL., TRENDS BIOTECHNOL., vol. 15, 1997, pages 26 - 32
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
CHOTHIA; LESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
MACCALLUM ET AL., J. MOL. BIOL., vol. 262, 1996, pages 732 - 745
INTERNATIONAL IMMUNOGENETICS INFORMATION SYSTEM, Retrieved from the Internet
EDELMAN G.M. ET AL.: "The covalent structure of an entire yG immunoglobulin molecule", PROC. NATL. ACAD. SCI. USA, vol. 63, no. 1, 1969, pages 78 - 85
JAKOBOVITS ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 2551 - 2555
JAKOBOVITS ET AL., NATURE, vol. 362, 1993, pages 255 - 258
BRUGGERMANN ET AL., YEAR IN IMMUNOL., vol. 7, 1993, pages 33 - 40
LI ET AL., PROC. NATL. ACAD. SCI. USA, vol. 103, 2006, pages 3557 - 3562
KOZBOR, J. IMMUNOL., vol. 133, 1984, pages 3001 - 3005
BRODEUR ET AL.: "Monoclonal Antibody Production Techniques and Applications", 1987, MARCEL DEKKER, INC., pages: 51 - 63
BOERNER ET AL., J. IMMUNOL., vol. 147, 1991, pages 86 - 95
MORIMOTO ET AL., JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, vol. 24, 1992, pages 107 - 117
BRENNAN ET AL., SCIENCE, vol. 229, 1985, pages 81 - 83
CARTER ET AL., BIOLTECHNOLOGY (NY), vol. 10, 1992, pages 163 - 167
TUTT ET AL., J. IMMUNOL., vol. 147, 1991, pages 60 - 69
MILSTEIN; CUELLO, NATURE, vol. 305, 1983, pages 537 - 539
TRAUNECKER ET AL., EMBO J., vol. 10, 1991, pages 3655 - 3559
SURESH ET AL., METHODS IN ENZYMOLOGY, vol. 121, 1986, pages 210 - 228
"Molecular Cloning: A Laboratory Manual", CSHL PRESS
"Current Protocols in Molecular Biology", JOHN WILEY & SONS, INC.
"Antibody Engineering", SPRINGER
"Antibodies: A Laboratory Manual", CSHL PRESS
YANIV, NATURE, vol. 297, 1982, pages 17 - 18
SKERRA ET AL., CURR. OPINION IN IMMUNOL., vol. 5, 1993, pages 256 - 262
PLUCKTHUN, IMMUNOL. REV., vol. 130, 1992, pages 151 - 188
CARTER ET AL., BIO/TECHNOLOGY (NY), vol. 10, 1992, pages 163 - 167
LINDMARK ET AL., J. IMMUNOL. METHODS, vol. 62, 1983, pages 1 - 13
GUSS ET AL., EMBO J., vol. 5, 1986, pages 1567 - 1575
SONGSIVILAI ET AL., CLIN. EXP. IMMUNOL., vol. 79, 1990, pages 315 - 321
SOWDHAMINI R. ET AL., PROTEIN ENG., 1989, pages 95 - 103
See also references of EP 2915819A4
WRIGHT ET AL., TRENDS BIOTECHNOL., vol. 15, 1997, pages 26 - 32
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
CHOTHIA; LESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
MACCALLUM ET AL., J. MOL. BIOL., vol. 262, 1996, pages 732 - 745
INTERNATIONAL IMMUNOGENETICS INFORMATION SYSTEM, Retrieved from the Internet
EDELMAN G.M. ET AL.: "The covalent structure of an entire yG immunoglobulin molecule", PROC. NATL. ACAD. SCI. USA, vol. 63, no. 1, 1969, pages 78 - 85
JAKOBOVITS ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 2551 - 2555
JAKOBOVITS ET AL., NATURE, vol. 362, 1993, pages 255 - 258
BRUGGERMANN ET AL., YEAR IN IMMUNOL., vol. 7, 1993, pages 33 - 40
LI ET AL., PROC. NATL. ACAD. SCI. USA, vol. 103, 2006, pages 3557 - 3562
KOZBOR, J. IMMUNOL., vol. 133, 1984, pages 3001 - 3005
BRODEUR ET AL.: "Monoclonal Antibody Production Techniques and Applications", 1987, MARCEL DEKKER, INC., pages: 51 - 63
BOERNER ET AL., J. IMMUNOL., vol. 147, 1991, pages 86 - 95
MORIMOTO ET AL., JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, vol. 24, 1992, pages 107 - 117
BRENNAN ET AL., SCIENCE, vol. 229, 1985, pages 81 - 83
CARTER ET AL., BIOLTECHNOLOGY (NY), vol. 10, 1992, pages 163 - 167
TUTT ET AL., J. IMMUNOL., vol. 147, 1991, pages 60 - 69
MILSTEIN; CUELLO, NATURE, vol. 305, 1983, pages 537 - 539
TRAUNECKER ET AL., EMBO J., vol. 10, 1991, pages 3655 - 3559
SURESH ET AL., METHODS IN ENZYMOLOGY, vol. 121, 1986, pages 210 - 228
"Molecular Cloning: A Laboratory Manual", CSHL PRESS
"Current Protocols in Molecular Biology", JOHN WILEY & SONS, INC.
"Antibody Engineering", SPRINGER
"Antibodies: A Laboratory Manual", CSHL PRESS
YANIV, NATURE, vol. 297, 1982, pages 17 - 18
SKERRA ET AL., CURR. OPINION IN IMMUNOL., vol. 5, 1993, pages 256 - 262
PLUCKTHUN, IMMUNOL. REV., vol. 130, 1992, pages 151 - 188
CARTER ET AL., BIO/TECHNOLOGY (NY), vol. 10, 1992, pages 163 - 167
LINDMARK ET AL., J. IMMUNOL. METHODS, vol. 62, 1983, pages 1 - 13
GUSS ET AL., EMBO J., vol. 5, 1986, pages 1567 - 1575
SONGSIVILAI ET AL., CLIN. EXP. IMMUNOL., vol. 79, 1990, pages 315 - 321
SOWDHAMINI R. ET AL., PROTEIN ENG., 1989, pages 95 - 103
Attorney, Agent or Firm:
SONODA Yoshitaka et al. (JP)
Yoshitaka Sonoda (JP)
Yoshitaka Sonoda (JP)
Download PDF: