Title:
ANTIBODY FOR DETECTING EPITHELIAL OVARIAN CANCER MARKER AND METHOD FOR DIAGNOSING EPITHELIAL OVARIAN CANCER
Document Type and Number:
WIPO Patent Application WO/2013/015367
Kind Code:
A1
Abstract:
An epithelial ovarian cancer marker with high specificity is found, and an antibody or fragment thereof that is capable of specifically recognizing and detecting said marker is provided. Provided is an antibody for an epithelial ovarian cancer marker, namely the glycosyltransferase β1,6-N-acetylglucosamine transferase (5B). Said antibody, which is used to diagnose epithelial ovarian cancer, recognizes an epitope consisting of part of the polypeptide comprising the amino acid sequence represented by sequence number 1, from β1,6-N-acetylglucosamine transferase (5B).
Inventors:
SOGABE MAKI (JP)
KUBOTA TOMOMI (JP)
TOGAYACHI AKIRA (JP)
IKEHARA YUZURU (JP)
NARIMATSU HISASHI (JP)
SAWAKI HIROMICHI (JP)
NAKANISHI HAYAO (JP)
NAKANISHI TORU (JP)
KUBOTA TOMOMI (JP)
TOGAYACHI AKIRA (JP)
IKEHARA YUZURU (JP)
NARIMATSU HISASHI (JP)
SAWAKI HIROMICHI (JP)
NAKANISHI HAYAO (JP)
NAKANISHI TORU (JP)
Application Number:
PCT/JP2012/068990
Publication Date:
January 31, 2013
Filing Date:
July 26, 2012
Export Citation:
Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
AICHI PREFECTURE (JP)
SOGABE MAKI (JP)
KUBOTA TOMOMI (JP)
TOGAYACHI AKIRA (JP)
IKEHARA YUZURU (JP)
NARIMATSU HISASHI (JP)
SAWAKI HIROMICHI (JP)
NAKANISHI HAYAO (JP)
NAKANISHI TORU (JP)
AICHI PREFECTURE (JP)
SOGABE MAKI (JP)
KUBOTA TOMOMI (JP)
TOGAYACHI AKIRA (JP)
IKEHARA YUZURU (JP)
NARIMATSU HISASHI (JP)
SAWAKI HIROMICHI (JP)
NAKANISHI HAYAO (JP)
NAKANISHI TORU (JP)
International Classes:
C12N15/09; C07K16/40; C12N5/10; G01N33/573; G01N33/574; C12N9/10; C12P21/08
Domestic Patent References:
| WO2009028417A1 | 2009-03-05 |
Foreign References:
| JPH03259093A | 1991-11-19 | |||
| EP0125023A1 | 1984-11-14 |
Other References:
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NORIKO TAKAHASHI ET AL.: "Ransogan ni Okeru N-Acetylglucosamine Ten'i Koso no Hatsugen no Igi", ACTA OBSTETRICA ET GYNAECOLOGIA JAPONICA, vol. 60, no. 2, 2008, pages 839, XP008173450
TAKAHASHI,N. ET AL.: "High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary", ONCOLOGY REPORTS, vol. 22, no. 5, 2009, pages 1027 - 1032, XP008173445
TOMOMI KUBOTA ET AL.: "Ransogan Bio Marker to shite no To Ten'i Koso", PREPRINTS OF BIOTECHNOLOGY SYMPOSIUM, vol. 28, 2010, pages 68 - 69, XP008173451
TOMOMI KUBOTA ET AL.: "Ransogan Bio Marker to shite no To Ten'i Koso", JAPAN SOCIETY FOR MOLECULAR TUMOR MARKER RESEARCH PROGRAM KOEN SHOROKU, vol. 30, 2010, pages 104 - 105, XP008173768
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OHUCHI N. ET AL., GAN TO KAGAKU RYOHO, vol. 15, 1988, pages 2767 - 2772
NOZAWA S. ET AL., NIPPON RINSHO, vol. 54, 1996, pages 1665 - 1673
CHARPIN C. ET AL., INT. J. GYNECOL. PATHOL., vol. 1, 1982, pages 231 - 245
SEKO A. ET AL., TUMOR BIOL., vol. 30, 2009, pages 43 - 50
KANEKO M. ET AL., FEBS LETTERS, vol. 554, 2003, pages 515 - 519
NISHIHARA S ET AL., BIOCHEM. BIOPHYS. RES. COMMUN, vol. 196, 1993, pages 624 - 631
SAMBROOK, J. ET AL.: "Molecular Cloning: A Laboratory Manual Second Ed.,", 1989, COLD SPRING HARBOR LABORATORY PRESS
PNAS, vol. 86, 1989, pages 6077
VIROLOGY, vol. 52, 1973, pages 456 - 467
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
KEARNEY J.F. ET AL., J. IMMUNOL., vol. 123, 1979, pages 1548 - 1550
YELTON D.E. ET AL., CURR. TOP. MICROBIOL. IMMUNOL., vol. 81, 1978, pages 1 - 7
KOHLER G. ET AL., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
MARGULIES D.H. ET AL., CELL, vol. 8, 1976, pages 405 - 415
SHULMAN M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
DE ST. GROTH S.F. ET AL., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
TROWBRIDGE LS., J. EXP. MED., vol. 148, 1978, pages 313 - 323
GALFRE G. ET AL., NATURE, vol. 277, 1979, pages 131 - 133
"Selected Methods in Cellular Immunology", 1980, W.H. FREEMAN AND COMPANY
NATURE, vol. 266, 1977, pages 550 - 552
"Pierce Catalog and Handbook", 1994, PIERCE CHEMICAL CO.
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
MARVIN ET AL., ACTA PHARMACOL. SIN., vol. 26, 2005, pages 649 - 658
OLAFSEN ET AL., PROT. ENGR. DES. SEL., vol. 17, 2004, pages 21 - 27
"Current protocols in Protein Sciences", 1995, JOHN WILEY & SONS INC.
"Current protocols in Immunology", 2001, JOHN WILEY & SONS INC.
UEMURA M. ET AL., CANCER RES., vol. 52, 1992, pages 6153 - 6157
NORIKO TAKAHASHI ET AL.: "Ransogan ni Okeru N-Acetylglucosamine Ten'i Koso no Hatsugen no Igi", ACTA OBSTETRICA ET GYNAECOLOGIA JAPONICA, vol. 60, no. 2, 2008, pages 839, XP008173450
TAKAHASHI,N. ET AL.: "High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary", ONCOLOGY REPORTS, vol. 22, no. 5, 2009, pages 1027 - 1032, XP008173445
TOMOMI KUBOTA ET AL.: "Ransogan Bio Marker to shite no To Ten'i Koso", PREPRINTS OF BIOTECHNOLOGY SYMPOSIUM, vol. 28, 2010, pages 68 - 69, XP008173451
TOMOMI KUBOTA ET AL.: "Ransogan Bio Marker to shite no To Ten'i Koso", JAPAN SOCIETY FOR MOLECULAR TUMOR MARKER RESEARCH PROGRAM KOEN SHOROKU, vol. 30, 2010, pages 104 - 105, XP008173768
BAST R.C. JR. ET AL., N. ENGL. J. MED., vol. 309, 1983, pages 883 - 887
SUZUKI M. ET AL., NIPPON GAN CHIRYO GAKKAI SHI, vol. 25, 1990, pages 1454 - 1460
INABA N. ET AL., NIPPON GAN CHIRYO GAKKAI SHI, vol. 24, 1989, pages 2426 - 2435
OHUCHI N. ET AL., GAN TO KAGAKU RYOHO, vol. 15, 1988, pages 2767 - 2772
NOZAWA S. ET AL., NIPPON RINSHO, vol. 54, 1996, pages 1665 - 1673
CHARPIN C. ET AL., INT. J. GYNECOL. PATHOL., vol. 1, 1982, pages 231 - 245
SEKO A. ET AL., TUMOR BIOL., vol. 30, 2009, pages 43 - 50
KANEKO M. ET AL., FEBS LETTERS, vol. 554, 2003, pages 515 - 519
NISHIHARA S ET AL., BIOCHEM. BIOPHYS. RES. COMMUN, vol. 196, 1993, pages 624 - 631
SAMBROOK, J. ET AL.: "Molecular Cloning: A Laboratory Manual Second Ed.,", 1989, COLD SPRING HARBOR LABORATORY PRESS
PNAS, vol. 86, 1989, pages 6077
VIROLOGY, vol. 52, 1973, pages 456 - 467
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
KEARNEY J.F. ET AL., J. IMMUNOL., vol. 123, 1979, pages 1548 - 1550
YELTON D.E. ET AL., CURR. TOP. MICROBIOL. IMMUNOL., vol. 81, 1978, pages 1 - 7
KOHLER G. ET AL., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
MARGULIES D.H. ET AL., CELL, vol. 8, 1976, pages 405 - 415
SHULMAN M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
DE ST. GROTH S.F. ET AL., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
TROWBRIDGE LS., J. EXP. MED., vol. 148, 1978, pages 313 - 323
GALFRE G. ET AL., NATURE, vol. 277, 1979, pages 131 - 133
"Selected Methods in Cellular Immunology", 1980, W.H. FREEMAN AND COMPANY
NATURE, vol. 266, 1977, pages 550 - 552
"Pierce Catalog and Handbook", 1994, PIERCE CHEMICAL CO.
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
MARVIN ET AL., ACTA PHARMACOL. SIN., vol. 26, 2005, pages 649 - 658
OLAFSEN ET AL., PROT. ENGR. DES. SEL., vol. 17, 2004, pages 21 - 27
"Current protocols in Protein Sciences", 1995, JOHN WILEY & SONS INC.
"Current protocols in Immunology", 2001, JOHN WILEY & SONS INC.
UEMURA M. ET AL., CANCER RES., vol. 52, 1992, pages 6153 - 6157
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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