Title:
ANTIBODY-DRUG COMPLEX
Document Type and Number:
WIPO Patent Application WO/2024/043319
Kind Code:
A1
Abstract:
An antibody-drug complex represented by formula (I): (in the formula, Ab is an antibody, X is a group represented by formula (X-1), formula (X-2), or formula (X-3): (in the formulas, AA on the left represents a binding site with NH, BB on the right represents a binding site with D.), D is a group represented by formula (D-1) or formula (D-2): (in the formulas, CC represents a binding site with X.), and n ranges from about 1 to about 8.).
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Inventors:
MIYANO MASAYUKI (JP)
NAKAZAWA YUYA (JP)
ISO KENTARO (JP)
YABE YUKI (JP)
UMIHARA HIROTATSU (JP)
TAGUCHI JUNICHI (JP)
INOUE SATOSHI (JP)
TSUKAMOTO SHUNTARO (JP)
KOGAI HIROYUKI (JP)
YAMAGUCHI ATSUMI (JP)
AKAGI TSUYOSHI (JP)
MUKAI YOHEI (JP)
HIRAYAMA TOSHIFUMI (JP)
KATO MASAKI (JP)
MOCHIZUKI TOSHIKI (JP)
YAMAMOTO AKIHIKO (JP)
YAMAMOTO YUJI (JP)
SAKURADA TAKATO (JP)
NAKAZAWA YUYA (JP)
ISO KENTARO (JP)
YABE YUKI (JP)
UMIHARA HIROTATSU (JP)
TAGUCHI JUNICHI (JP)
INOUE SATOSHI (JP)
TSUKAMOTO SHUNTARO (JP)
KOGAI HIROYUKI (JP)
YAMAGUCHI ATSUMI (JP)
AKAGI TSUYOSHI (JP)
MUKAI YOHEI (JP)
HIRAYAMA TOSHIFUMI (JP)
KATO MASAKI (JP)
MOCHIZUKI TOSHIKI (JP)
YAMAMOTO AKIHIKO (JP)
YAMAMOTO YUJI (JP)
SAKURADA TAKATO (JP)
Application Number:
PCT/JP2023/030603
Publication Date:
February 29, 2024
Filing Date:
August 24, 2023
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
A61K47/68; A61K31/498; A61K47/54; C07D401/04; C07D401/14; C07D405/14; C07D471/04; C07D491/048
Domestic Patent References:
| WO2021053495A1 | 2021-03-25 | |||
| WO2021077010A1 | 2021-04-22 |
Foreign References:
| JP2019501140A | 2019-01-17 | |||
| JP2022534472A | 2022-08-01 | |||
| JP2020503321A | 2020-01-30 |
Other References:
YANG SHYH-MING; URBAN DANIEL J.; YOSHIOKA MAKOTO; STROVEL JEFFREY W.; FLETCHER STEVEN; WANG AMY Q.; XU XIN; SHAH PRANAV; HU XIN; H: "Discovery and lead identification of quinazoline-based BRD4 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 28, no. 21, 31 August 2018 (2018-08-31), Amsterdam NL , pages 3483 - 3488, XP085499074, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2018.08.039
LIN SONGWEN; HAN FANGBIN; LIU PENG; TAO JING; ZHONG XUECHAO; LIU XIUJIE; YI CHONGQIN; XU HENG: "Identification of novel 7-amino-5-methyl-1,6-naphthyridin-2(1H)-one derivatives as potent PI3K/mTOR dual inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 24, no. 3, 3 January 2014 (2014-01-03), Amsterdam NL , pages 790 - 793, XP028819918, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2013.12.112
LIN SONGWEN; HAN FANGBIN; LIU PENG; TAO JING; ZHONG XUECHAO; LIU XIUJIE; YI CHONGQIN; XU HENG: "Identification of novel 7-amino-5-methyl-1,6-naphthyridin-2(1H)-one derivatives as potent PI3K/mTOR dual inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 24, no. 3, 3 January 2014 (2014-01-03), Amsterdam NL , pages 790 - 793, XP028819918, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2013.12.112
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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