ANTIBODY-DRUG CONJUGATE HAVING CAMPTOTHECIN-BASED DRUG LINKED TO ANTIBODY HAVING LOW ANTIGEN-BINDING AFFINITY THROUGH LINKER

WIPO Patent Application WO/2024/049220

A1

The present invention relates to an immunoconjugate or a pharmaceutically acceptable salt thereof characterized in that a camptothecin-based drug (A) is bound, through a linker (C), to: an antibody or an antigen-binding fragment (B-1) thereof having a dissociation constant Kd value of 1*10-8 M to 1*10-6 M (exclusive of 1*10-6 M) with respect to an epitope of a cell surface protein; or an antibody or antigen-binding fragment (B-2) thereof which binds to a cell surface protein expressed in both normal cells and cancer cells and which has a higher binding affinity with respect to an epitope of the cell surface protein when binding divalently than when binding monovalently.

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JUNG DOO YOUNG (KR)
LEE JIN SOO (KR)
CHO HYUN YONG (KR)
LEE BYEONG SUNG (KR)
CHUN YOUNG HWA (KR)
SHIN SEUNG GUN (KR)
KWEON SO HUI (KR)
GO AREUM (KR)

PCT/KR2023/012935

March 07, 2024

August 30, 2023

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PINOTBIO INC (KR)

A61K47/68; A61K31/4745; A61K47/65; A61P35/00; C07D491/22; G01N33/574

WO2021190581A1	2021-09-30
WO2022015110A1	2022-01-20
WO2021149817A1	2021-07-29

CN111001012A	2020-04-14
KR20220079606A	2022-06-13

IPUS PATENT & LAW FIRM (KR)

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