ANTIBODY DRUG CONJUGATE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF

Title:

ANTIBODY DRUG CONJUGATE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2016/197946

Kind Code:

A1

Abstract:

Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in vitro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.

Inventors:

XIANG SHAOYUN (CN)
LIU SHIFENG (CN)
YANG HONGYU (CN)
MA XINGQUAN (CN)

Application Number:

PCT/CN2016/085275

Publication Date:

December 15, 2016

Filing Date:

June 08, 2016

Export Citation:

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Assignee:

XDCEXPLORER (SHANGHAI) CO LTD (CN)

International Classes:

A61K47/48; A61K31/537; A61K39/395; A61P35/00

Foreign References:

CN103269712A	2013-08-28
CN103319599A	2013-09-25

Other References:

JAIN, N. ET AL.: "Current ADC Linker Chemistry", PHARMRES., vol. 32, no. 11, 11 March 2015 (2015-03-11), pages 3526 - 3540, XP035553874, ISSN: 0724-8741
JAIN, N. ET AL.: "Current ADC Linker Chemistry", PHARMRES, vol. 32, no. 11, 11 March 2015 (2015-03-11), pages 3526 - 3540, XP035553874, ISSN: 0724-8741
LEWIS, P.G. ET AL.: "Targeting HER2-Positive Breast Cancer with Trastuzumab-DMl, an Antibody-Cytotoxic Drug Conjugate", CANCER RES., vol. 68, no. 22, 15 November 2008 (2008-11-15), pages 9280 - 9290, XP055013498, ISSN: 2321-7758
See also references of EP 3308801A4

Attorney, Agent or Firm:

SHANGHAI BESHINING LAW OFFICE (CN)
上海弼兴律师事务所 (CN)

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