Title:
ANTIBODY-DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/012523
Kind Code:
A1
Abstract:
A bioactive conjugate, and a preparation method therefor and the use thereof. Specifically, disclosed are an antibody-drug conjugate as represented by formula (XV), a preparation method therefor and the use thereof in the prevention and/or treatment of diseases related to abnormal cell activity, including, but not limited to, the use thereof in the prevention and/or treatment of tumor diseases.
Inventors:
XIAO LIANG (CN)
CAI JIAQIANG (CN)
XUE TONGTONG (CN)
CAI JIAQIANG (CN)
XUE TONGTONG (CN)
Application Number:
PCT/CN2023/107218
Publication Date:
January 18, 2024
Filing Date:
July 13, 2023
Export Citation:
Assignee:
MEDILINK THERAPEUTICS SUZHOU CO LTD (CN)
International Classes:
A61K47/68; A61K39/00; A61P35/00; C07D491/22; C07K16/28
Domestic Patent References:
| WO2022170971A1 | 2022-08-18 | |||
| WO2021228141A1 | 2021-11-18 | |||
| WO2011093097A1 | 2011-08-04 |
Foreign References:
| CN113766954A | 2021-12-07 | |||
| US20190201542A1 | 2019-07-04 | |||
| US20210283125A1 | 2021-09-16 | |||
| CN113603703A | 2021-11-05 | |||
| CN102574866A | 2012-07-11 | |||
| CN106163559A | 2016-11-23 | |||
| CN114746115A | 2022-07-12 | |||
| CN113891731A | 2022-01-04 |
Other References:
WEI, BINQING ET AL.: "Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, 11 December 2017 (2017-12-11), pages 989 - 1000, XP055670654, DOI: 10.1021/acs.jmedchem.7b01430
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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