Title:
ANTIBODY-DRUG CONJUGATES AND IMMUNOTOXINS
Document Type and Number:
WIPO Patent Application WO/2015/118031
Kind Code:
A3
Abstract:
The present invention relates to conjugates, in particular antibody- drug conjugates and iramunotoxins, having the formula (I): A-(L-D)p (I) or a pharmaceutically acceptable salts or solvates thereof, wherein : A is an antibody that selectively binds Endoglin; L is a linker; D is a drug comprising a cytolysin or a Nigrin-b A-chain; and p is 1 to 10, and to use of such conjugates in the therapeutic treatment of tumors. Methods of producing such conjugates and components for use in such methods are disclosed.
Inventors:
KONTERMANN ROLAND (ES)
PFIZENMAIER KLAUS (ES)
FERRER CRISTINA (ES)
FABRE MYRIAM (ES)
SIMON LAUREANO (ES)
PFIZENMAIER KLAUS (ES)
FERRER CRISTINA (ES)
FABRE MYRIAM (ES)
SIMON LAUREANO (ES)
Application Number:
PCT/EP2015/052342
Publication Date:
October 01, 2015
Filing Date:
February 04, 2015
Export Citation:
Assignee:
ONCOMATRYX BIOPHARMA S L (ES)
International Classes:
C07K16/28; A61K47/48
Domestic Patent References:
| WO2012135517A2 | 2012-10-04 | |||
| WO2008138561A1 | 2008-11-20 | |||
| WO2010126551A1 | 2010-11-04 |
Other References:
JOSÉ M. FERRERAS ET AL: "Use of Ribosome-Inactivating Proteins from Sambucus for the Construction of Immunotoxins and Conjugates for Cancer Therapy", TOXINS, vol. 3, no. 12, 29 December 2011 (2011-12-29), pages 420 - 441, XP055189134, ISSN: 2072-6651, DOI: 10.3390/toxins3050420
CYNTHIA CHALLENER: "Site-Specific Conjugation of Cytotoxic Cytolysins Could Lead to Highly Effective Antibody-Drug Conjugates", PHARMTECH, 13 November 2013 (2013-11-13), XP055189329, Retrieved from the Internet [retrieved on 20150513]
ELS J. M. DAMME ET AL: "Characterization and Molecular Cloning of Sambucus nigra Agglutinin V (Nigrin b), A Galnac-specific Type-2 Ribosome-Inactivating Protein from the Bark of Elderberry (Sambucus nigra)", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 237, no. 2, 15 April 1996 (1996-04-15), pages 505 - 513, XP055189299, ISSN: 0014-2956, DOI: 10.1111/j.1432-1033.1996.0505k.x
RAQUEL MUÑOZ ET AL: "In vitro and in vivo effects of an anti-mouse endoglin (CD105)-immunotoxin on the early stages of mouse B16MEL4A5 melanoma tumours", CANCER IMMUNOLOGY, IMMUNOTHERAPY, vol. 62, no. 3, 1 March 2013 (2013-03-01), pages 541 - 551, XP055189142, ISSN: 0340-7004, DOI: 10.1007/s00262-012-1357-7
ROGER GILABERT-ORIOL ET AL: "Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy", CURRENT PHARMACEUTICAL DESIGN, vol. 20, no. 42, 22 October 2014 (2014-10-22), pages 6584 - 6643, XP055189313, ISSN: 1381-6128, DOI: 10.2174/1381612820666140826153913
CYNTHIA CHALLENER: "Site-Specific Conjugation of Cytotoxic Cytolysins Could Lead to Highly Effective Antibody-Drug Conjugates", PHARMTECH, 13 November 2013 (2013-11-13), XP055189329, Retrieved from the Internet
ELS J. M. DAMME ET AL: "Characterization and Molecular Cloning of Sambucus nigra Agglutinin V (Nigrin b), A Galnac-specific Type-2 Ribosome-Inactivating Protein from the Bark of Elderberry (Sambucus nigra)", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 237, no. 2, 15 April 1996 (1996-04-15), pages 505 - 513, XP055189299, ISSN: 0014-2956, DOI: 10.1111/j.1432-1033.1996.0505k.x
RAQUEL MUÑOZ ET AL: "In vitro and in vivo effects of an anti-mouse endoglin (CD105)-immunotoxin on the early stages of mouse B16MEL4A5 melanoma tumours", CANCER IMMUNOLOGY, IMMUNOTHERAPY, vol. 62, no. 3, 1 March 2013 (2013-03-01), pages 541 - 551, XP055189142, ISSN: 0340-7004, DOI: 10.1007/s00262-012-1357-7
ROGER GILABERT-ORIOL ET AL: "Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy", CURRENT PHARMACEUTICAL DESIGN, vol. 20, no. 42, 22 October 2014 (2014-10-22), pages 6584 - 6643, XP055189313, ISSN: 1381-6128, DOI: 10.2174/1381612820666140826153913
Attorney, Agent or Firm:
CASLEY, Christopher et al. (33 Gutter LaneLondon, Greater London EC2V 8AS, GB)
Download PDF:
Previous Patent: ANTIBODY-DRUG CONJUGATES AND IMMUNOTOXINS
Next Patent: SURFACE CLEANING SYSTEM AND METHOD
Next Patent: SURFACE CLEANING SYSTEM AND METHOD