Title:
ANTIBODY OR ANTIBODY FRAGMENT THAT SPECIFICALLY BINDS TO VOLTAGE-GATED SODIUM CHANNEL α SUBUNIT NAV1.7
Document Type and Number:
WIPO Patent Application WO/2022/241752
Kind Code:
A1
Abstract:
The present invention provides an antibody or antibody fragment that targets cell membrane voltage-gated sodium ion channel α subunit Nav 1.7; a specific binding target thereof is an ion-conducting pore module (PM) of an S3 domain of domain IV of a voltage-gated sodium ion channel α subunit. The antibody or antibody fragment thereof can inactivate the ion-conducting PM, so that sodium ions cannot normally enter nerve cells, to thereby achieve the effect of treating and relieving pain.
Inventors:
YANG DAICHANG (CN)
Application Number:
PCT/CN2021/095059
Publication Date:
November 24, 2022
Filing Date:
May 21, 2021
Export Citation:
Assignee:
POPULAS BIOPHARMACEUTICAL WUHAN LTD (CN)
International Classes:
C07K16/18; A61K39/395; A61P29/00; C12N15/13; C12N15/63
Domestic Patent References:
| WO2015032916A1 | 2015-03-12 |
Foreign References:
| CN113527479A | 2021-10-22 | |||
| CN112368383A | 2021-02-12 |
Attorney, Agent or Firm:
LECOME INTELLECTUAL PROPERTY AGENT LTD. (CN)
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