Title:
ANTIBODY OR FRAGMENT THEREOF BINDING SPECIFICALLY TO MERTK, AND ANTI-TUMOR AGENT
Document Type and Number:
WIPO Patent Application WO/2023/063026
Kind Code:
A1
Abstract:
A problem addressed by the present invention is to provide an anti-MerTK antibody that has a tumor-suppressing effect and does not tend to cause ocular toxicity. The present invention provides an antibody or a fragment thereof that binds specifically to MerTK, in which the amino acid sequences of heavy chain and light chain CDRs 1 to 3 satisfy predetermined requirements.
Inventors:
TOYOURA MASAYOSHI (JP)
KAMBAYASHI HIROAKI (JP)
SAWADA ATSUSHI (JP)
TAKESUE AKI (JP)
INOUE TOSHIKAZU (JP)
KAMBAYASHI HIROAKI (JP)
SAWADA ATSUSHI (JP)
TAKESUE AKI (JP)
INOUE TOSHIKAZU (JP)
Application Number:
PCT/JP2022/034801
Publication Date:
April 20, 2023
Filing Date:
September 16, 2022
Export Citation:
Assignee:
CHIOME BIOSCIENCE INC (JP)
International Classes:
C07K16/40; A61K39/395; A61K45/00; A61P35/00; A61P43/00; C12N15/13
Domestic Patent References:
| WO2021119508A1 | 2021-06-17 | |||
| WO2020076799A1 | 2020-04-16 |
Other References:
PHARMACOL THER, vol. 225, 10 March 2021 (2021-03-10), pages 107822
IMMUNITY, vol. 52, no. 2, 18 February 2020 (2020-02-18), pages 357 - 373
TOXICOL PATHOL, vol. 46, no. 2, February 2018 (2018-02-01), pages 193 - 201
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 42, no. 9, August 2001 (2001-08-01)
NEURON, vol. 76, no. 6, 20 December 2012 (2012-12-20), pages 1123 - 32
KABAT ET AL.: "Sequences of Proteins of Immunological Interests", 1991, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
TSURUSHITA ET AL.: "Design of humanized antibodies: From anti-Tac to Zenapax", METHODS, vol. 36, 2005, pages 69 - 83, XP004852554, DOI: 10.1016/j.ymeth.2005.01.007
IMMUNITY, vol. 52, no. 2, 18 February 2020 (2020-02-18), pages 357 - 373
TOXICOL PATHOL, vol. 46, no. 2, February 2018 (2018-02-01), pages 193 - 201
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 42, no. 9, August 2001 (2001-08-01)
NEURON, vol. 76, no. 6, 20 December 2012 (2012-12-20), pages 1123 - 32
KABAT ET AL.: "Sequences of Proteins of Immunological Interests", 1991, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
TSURUSHITA ET AL.: "Design of humanized antibodies: From anti-Tac to Zenapax", METHODS, vol. 36, 2005, pages 69 - 83, XP004852554, DOI: 10.1016/j.ymeth.2005.01.007
Attorney, Agent or Firm:
SHOBAYASHI Masayuki (JP)
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