Title:
ANTIBODY FUSION PROTEINS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/199603
Kind Code:
A1
Abstract:
An antibody fusion protein comprising: i) a multivalent (e.g., bivalent) antibody or antigen-binding fragment thereof specifically recognizing Angiopoietin-2 (Ang2) ( "multivalent anti-Ang2 antibody or antigen-binding fragment thereof" ), and ii) a vascular endothelial growth factor receptor (VEGFR) component, wherein the multivalent anti-Ang2 antibody or antigen-binding fragment thereof does not inhibit the binding between Ang2 and TEK receptor tyrosine kinase (TIE2). Also provided are methods of making and uses thereof.
Inventors:
LI ZHONGDAO (CN)
JIN YI (CN)
JIA WENSHUANG (CN)
WANG WEIMING (CN)
ZHAO ZHIHUI (CN)
MIN BRIAN HOSUNG (CN)
SHAO CUIYING (CN)
JIN YI (CN)
JIA WENSHUANG (CN)
WANG WEIMING (CN)
ZHAO ZHIHUI (CN)
MIN BRIAN HOSUNG (CN)
SHAO CUIYING (CN)
Application Number:
PCT/CN2022/082448
Publication Date:
September 29, 2022
Filing Date:
March 23, 2022
Export Citation:
Assignee:
NANJING GENSCRIPT BIOTECH CO LTD (CN)
International Classes:
C07K19/00; A61K39/395; A61P35/00; A61P37/06; A61P43/00; C07K16/18; C07K16/46
Domestic Patent References:
| WO2019075270A1 | 2019-04-18 | |||
| WO2015109898A1 | 2015-07-30 | |||
| WO2006020706A2 | 2006-02-23 |
Foreign References:
| CN101370519A | 2009-02-18 | |||
| US20180334499A1 | 2018-11-22 | |||
| US20190343918A1 | 2019-11-14 |
Other References:
PARK JIN-SUNG; KIM IL-KUG; HAN SANGYEUL; PARK INTAE; KIM CHAN; BAE JEOMIL; OH SEUNG JA; LEE SEUNGJOO; KIM JEONG HOON; WOO DONG-CHE: "Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment", CANCER CELL, CELL PRESS, US, vol. 30, no. 6, 12 December 2016 (2016-12-12), US , pages 953 - 967, XP029845233, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2016.10.018
CHENG QIAN, ZHENG WEI-WEI, WEI ZOU, CHUN-MEI YANG, SHAN ZHANG, YUAN-YUAN WU, YIN LU, AI-YUN WANG: "Research progress on the role of Ang/Tie axis in angiogenesis and metastasis", ACTA PHARMACEUTICA SINICA, vol. 55, no. 10, 1 January 2020 (2020-01-01), pages 2291 - 2297, XP055970019, DOI: 10.16438/j.0513-4870.2020-0045
CHENG QIAN, ZHENG WEI-WEI, WEI ZOU, CHUN-MEI YANG, SHAN ZHANG, YUAN-YUAN WU, YIN LU, AI-YUN WANG: "Research progress on the role of Ang/Tie axis in angiogenesis and metastasis", ACTA PHARMACEUTICA SINICA, vol. 55, no. 10, 1 January 2020 (2020-01-01), pages 2291 - 2297, XP055970019, DOI: 10.16438/j.0513-4870.2020-0045
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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