ANTIBODY HAVING IMPROVED STABILITY AND SPECIFICALLY BINDING TO HER2

Title:

ANTIBODY HAVING IMPROVED STABILITY AND SPECIFICALLY BINDING TO HER2

Document Type and Number:

WIPO Patent Application WO/2017/179862

Kind Code:

A1

Abstract:

The present invention replaces an amino acid residue of a specific region of a parent antibody so as to improve the stability of the antibody, thereby improving druggability. A variant antibody of the present invention, compared to a parent antibody hz1E11, has significantly improved stability while having nearly the same productivity and efficacy. Therefore, the variant antibody of the present invention exhibits, in the development of HER2-specific antibodies, excellent characteristics such as reduction in production costs, inhibition of efficacy reduction and reduction of side effects.

Inventors:

LEE JONG SEO (KR)
KIM KYU TAE (KR)
LEE YOUNG HA (KR)
HWANG IN SIK (KR)
KO BONG KOOK (KR)

Application Number:

PCT/KR2017/003827

Publication Date:

October 19, 2017

Filing Date:

April 12, 2017

Export Citation:

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Assignee:

ABCLON INC (KR)

International Classes:

C07K16/32; A61K39/00; A61K39/395; G01N33/574

Domestic Patent References:

WO2015074528A1

2015-05-28

Foreign References:

KR101453462B1	2014-10-23
KR20030074634A	2003-09-19
US8609095B2	2013-12-17
US20100047230A1	2010-02-25

Other References: