Title:
ANTIBODY HIGHLY SPECIFICALLY RECOGNIZING TURN STRUCTURE AT 22- AND 23-POSITIONS IN AMYLOID β
Document Type and Number:
WIPO Patent Application WO/2016/092865
Kind Code:
A1
Abstract:
Provided is an antibody or an immunologically reactive fragment thereof which targets exclusively an Aβ having a specific turn structure of Aβ (a toxic conformer of Aβ). Also provided are a medicinal composition comprising, as an active ingredient, an antibody that specifically recognizes a toxic conformer of Aβ, a kit for assaying a toxic conformer of Aβ, a diagnostic agent for Alzheimer's disease, etc.
Inventors:
IRIE KAZUHIRO (JP)
MURAKAMI KAZUMA (JP)
SHIMIZU TAKAHIKO (JP)
IZUO NAOTAKA (JP)
SEITO TSUTOMU (JP)
MURAKAMI KAZUMA (JP)
SHIMIZU TAKAHIKO (JP)
IZUO NAOTAKA (JP)
SEITO TSUTOMU (JP)
Application Number:
PCT/JP2015/006224
Publication Date:
June 16, 2016
Filing Date:
December 14, 2015
Export Citation:
Assignee:
UNIV KYOTO (JP)
UNIV CHIBA NAT UNIV CORP (JP)
IMMUNO BIOLOGICAL LAB CO LTD (JP)
UNIV CHIBA NAT UNIV CORP (JP)
IMMUNO BIOLOGICAL LAB CO LTD (JP)
International Classes:
C12N15/09; A61K39/395; A61P25/28; C07K16/18; C12N15/02; G01N33/53
Domestic Patent References:
| WO2011045945A1 | 2011-04-21 |
Foreign References:
| JP2006265189A | 2006-10-05 |
Other References:
MURAKAMI, KAZUMA ET AL.: "Monoclonal Antibody Against the Turn of the 42-Residue Amyloid B- Protein at Positions 22 and 23", ACS CHEM. NEUROSCI., vol. 1, no. 11, 2010, pages 747 - 756, XP008156477, doi:10.1021/cn100072e
"About Alzheimer's Disease: Alzheimer's Basics", 23 November 2014 (2014-11-23), XP055454088, Retrieved from the Internet [retrieved on 20160114]
MASUDA, YUICHI ET AL.: "Identification of physiological and toxic conformations in AP 42 aggregates", CHEMBIOCHEM., vol. 10, 2009, pages 287 - 295, XP008156384, doi:10.1002/cbic.200800411
MURAKAMI, KAZUMA ET AL.: "Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease", J. BIOL. CHEM., vol. 278, no. 46, 2003, pages 46179 - 46187, XP055454089
See also references of EP 3239295A4
"About Alzheimer's Disease: Alzheimer's Basics", 23 November 2014 (2014-11-23), XP055454088, Retrieved from the Internet
MASUDA, YUICHI ET AL.: "Identification of physiological and toxic conformations in AP 42 aggregates", CHEMBIOCHEM., vol. 10, 2009, pages 287 - 295, XP008156384, doi:10.1002/cbic.200800411
MURAKAMI, KAZUMA ET AL.: "Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease", J. BIOL. CHEM., vol. 278, no. 46, 2003, pages 46179 - 46187, XP055454089
See also references of EP 3239295A4
Attorney, Agent or Firm:
HASEGAWA, Hiroshi et al. (JP)
Hiroshi Hasegawa (JP)
Hiroshi Hasegawa (JP)
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