Title:
ANTIBODY-LINKER-DRUG CONJUGATE, PREPARATION METHOD THEREFOR, AND ANTICANCER DRUG COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2014/107024
Kind Code:
A1
Abstract:
The present invention relates to an antibody-linker-drug conjugate in which an antibody and a cytotoxic drug are conjugated through an enzyme cleavable peptide linker capable of directly binding to a lysine residue of an antibody, a preparation method therefor, and an anticancer drug composition containing the same as an active ingredient.
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Inventors:
PARK YOUNG JUN (KR)
JEONG JIN-KYO (KR)
CHOI YOUNG MI (KR)
LEE MINSEOB (KR)
KIM YEON JUNG (KR)
KIM KYOUNG SUK (KR)
CHOI JOON HUN (KR)
LEE JIN SEO (KR)
CHO EUN JOO (KR)
SONG HYUNNAM (KR)
PARK SUNG JUN (KR)
LEE JONG-HYOUP (KR)
LEE MATTHEW SANGYUP (KR)
LEE IN-SUK (KR)
KIM JOON WOO (KR)
HONG SEUNG SUH (KR)
JEONG JIN-KYO (KR)
CHOI YOUNG MI (KR)
LEE MINSEOB (KR)
KIM YEON JUNG (KR)
KIM KYOUNG SUK (KR)
CHOI JOON HUN (KR)
LEE JIN SEO (KR)
CHO EUN JOO (KR)
SONG HYUNNAM (KR)
PARK SUNG JUN (KR)
LEE JONG-HYOUP (KR)
LEE MATTHEW SANGYUP (KR)
LEE IN-SUK (KR)
KIM JOON WOO (KR)
HONG SEUNG SUH (KR)
Application Number:
PCT/KR2014/000005
Publication Date:
July 10, 2014
Filing Date:
January 02, 2014
Export Citation:
Assignee:
CELLTRION (KR)
International Classes:
C07D403/12; A61K38/08; A61K39/395; A61K39/44; A61K47/48
Foreign References:
| US7750116B1 | 2010-07-06 | |||
| US6214345B1 | 2001-04-10 | |||
| US7964566B2 | 2011-06-21 |
Other References:
DUCRY, LAURENT ET AL.: "Antibody-Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies", BIOCONJUGATE CHEM., vol. 21, 2010, pages 5 - 13, XP055000588
ALLEY, STEPHEN C. ET AL.: "Contribution of linker stability to the activities of anticancer immunoconjugates", BIOCONJUGATE CHEM., vol. 19, 2008, pages 759 - 765, XP055037546
SHARKEY ET AL., ADV. DRUG DEL. REV., 2008, pages 1407 - 1420
CHARI, ACC. CHEM. RES., vol. 41, 2008, pages 98 - 107
HAMBLETT ET AL., CLIN. CANCER RES., vol. 10, 15 October 1999 (1999-10-15), pages 7063 - 7070
DUBOWCHIK ET AL., BIOCONJUGATE CHEM., vol. 13, no. 4, 2002, pages 855 - 869
See also references of EP 2927227A4
ALLEY, STEPHEN C. ET AL.: "Contribution of linker stability to the activities of anticancer immunoconjugates", BIOCONJUGATE CHEM., vol. 19, 2008, pages 759 - 765, XP055037546
SHARKEY ET AL., ADV. DRUG DEL. REV., 2008, pages 1407 - 1420
CHARI, ACC. CHEM. RES., vol. 41, 2008, pages 98 - 107
HAMBLETT ET AL., CLIN. CANCER RES., vol. 10, 15 October 1999 (1999-10-15), pages 7063 - 7070
DUBOWCHIK ET AL., BIOCONJUGATE CHEM., vol. 13, no. 4, 2002, pages 855 - 869
See also references of EP 2927227A4
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