ANTIBODY SPECIFICALLY BINDING TO PAUF PROTEIN, AND USE THEREOF

WIPO Patent Application WO/2019/022274

A1

The present invention relates to an antibody specifically binding to a pancreatic adenocarcinoma upregulated factor (PAUF) protein, and a use thereof. The antibody of the present invention binds to the PAUF protein with high specificity and affinity and inhibits the proliferation, migration, penetration and in vivo growth of cancer cells, thereby being effectively used in the field of diagnosis and treatment of diseases, such as cancer, in which the PAUF protein is overexpressed.

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KOH SANG SEOK (KR)
KIM YEON JEONG (KR)
YOUN SO EUN (KR)
KIM SONG CHEOL (KR)
HONG SEUNG-MO (KR)
JEONG SEONG YUN (KR)

PCT/KR2017/008173

January 31, 2019

July 28, 2017

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UNIV DONG A RES FOUND FOR IND ACAD COOP (KR)
PRESTIGE BIOPHARMA PTE LTD (SG)

C07K16/18; A61K39/00; A61K47/50; G01N33/574

WO2007145466A1

2007-12-21

KR101098186B1	2011-12-23
KR101504039B1	2015-03-19
KR20170008893A	2017-01-24

KIM, YUN-HEE ET AL.: "Efficient Targeting and Tumor Retardation Effect of Pancreatic Adenocarcinoma Up-regulated Factor (PAUF)-specific RNA Replacement in Pancreatic Cancer Mouse Model", CANCER LETTERS, vol. 344, no. 2, 2014, pages 223 - 231, XP028827175
KIM, SUN A. ET AL.: "Pancreatic Adenocarcinoma Up-regulated Factor (PAUF), a Novel Up-regulated Secretory Protein in Pancreatic Ductal Adenocarcinoma", CANCER SCIENCE, vol. 100, no. 5, May 2009 (2009-05-01), pages 828 - 836, XP002552476

SON, Min (KR)

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