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Title:
ANTIBODY SPECIFICALLY BINDING TO PAUF PROTEIN, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/022274
Kind Code:
A1
Abstract:
The present invention relates to an antibody specifically binding to a pancreatic adenocarcinoma upregulated factor (PAUF) protein, and a use thereof. The antibody of the present invention binds to the PAUF protein with high specificity and affinity and inhibits the proliferation, migration, penetration and in vivo growth of cancer cells, thereby being effectively used in the field of diagnosis and treatment of diseases, such as cancer, in which the PAUF protein is overexpressed.

Inventors:
KOH, Sang Seok (103-1301, 22 Myeongji ocean city 11-ro,,Gangseo-gu, Busan, 46765, KR)
KIM, Yeon Jeong (16 Mobunjae-ro 132beon-gil, Buk-gu, Busan, 46623, KR)
YOUN, So Eun (205-406, 32 Songdong-ro 2-gil,,Gumi-si, Gyeongsangbuk-do, 39215, KR)
KIM, Song Cheol (221-2002, 435 Olympic-ro,,Songpa-gu, Seoul, 05507, KR)
HONG, Seung-Mo (304-601, 314 Yeoksam-ro,,Gangnam-gu, Seoul, 06217, KR)
JEONG, Seong Yun (510-801, 11 Sinbong 1-ro, Suji-gu,,Yongin-si, Gyeonggi-do, 16845, KR)
Application Number:
KR2017/008173
Publication Date:
January 31, 2019
Filing Date:
July 28, 2017
Export Citation:
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Assignee:
DONG-A UNIVERSITY RESEARCH FOUNDATION FOR INDUSTRY-ACADEMY COOPERATION (37 Nakdong-daero 550beon-gil, Saha-gu, Busan, 49315, KR)
PRESTIGE BIOPHARMA PTE. LTD. (2 Science Park Drive, #04-13/14 Ascent Tower B Singapore Science Park, Singapore 2, 118222, SG)
International Classes:
C07K16/18; A61K39/00; A61K47/50; G01N33/574
Domestic Patent References:
WO2007145466A12007-12-21
Foreign References:
KR101098186B12011-12-23
KR101504039B12015-03-19
KR20170008893A2017-01-24
Other References:
KIM, YUN-HEE ET AL.: "Efficient Targeting and Tumor Retardation Effect of Pancreatic Adenocarcinoma Up-regulated Factor (PAUF)-specific RNA Replacement in Pancreatic Cancer Mouse Model", CANCER LETTERS, vol. 344, no. 2, 2014, pages 223 - 231, XP028827175
KIM, SUN A. ET AL.: "Pancreatic Adenocarcinoma Up-regulated Factor (PAUF), a Novel Up-regulated Secretory Protein in Pancreatic Ductal Adenocarcinoma", CANCER SCIENCE, vol. 100, no. 5, May 2009 (2009-05-01), pages 828 - 836, XP002552476
Attorney, Agent or Firm:
SON, Min (Hanol Intellectual Property&Law, 6th Floor 163, YangJaeCheon-ro,,Gangnam-gu, Seoul, 06302, KR)
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