Title:
ANTIBODY FOR SPECIFICALLY RECOGNIZING CLEAVAGE SURFACE OF C-TERMINAL FRAGMENT AFTER α-SECRETASE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/167826
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an antibody for specifically recognizing α-secretase cleavage products of APP. In particular, the present invention provides an antibody for recognizing αCTF and p3 peptide, particularly antibodies that do not recognize βCTF and Aβ. The present invention also provides antigen-binding fragments of such antibodies. The present invention also provides an αCTF and/or p3 peptide measurement method and a measurement kit using such antibodies or an antigen-binding fragment thereof.
Inventors:
SEITO TSUTOMU (JP)
SEGAWA TATSUYA (JP)
SEGAWA TATSUYA (JP)
Application Number:
PCT/JP2014/001982
Publication Date:
October 16, 2014
Filing Date:
April 07, 2014
Export Citation:
Assignee:
IMMUNO BIOLOGICAL LAB CO LTD (JP)
International Classes:
C07K16/18; C12N15/02; G01N33/53
Domestic Patent References:
| WO2008061013A2 | 2008-05-22 |
Foreign References:
| JP2005529953A | 2005-10-06 | |||
| JP2013507115A | 2013-03-04 |
Other References:
TIAN YUAN ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 42, 15 October 2010 (2010-10-15), pages 32549 - 32556
Attorney, Agent or Firm:
HASEGAWA, Hiroshi et al. (JP)
Hiroshi Hasegawa (JP)
Hiroshi Hasegawa (JP)
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