Title:
ANTIBODY SPECIFICALLY TARGETING TUMOR EPCAM ANTIGEN AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/044991
Kind Code:
A1
Abstract:
Provided is a chimeric antigen receptor specifically targeting a tumor EpCAM antigen, comprising an extracellular antigen recognition domain, a transmembrane domain and an intracellular signaling domain, the extracellular antigen recognition domain comprising a VHH antibody or a fragment thereof, and the VHH antibody or the fragment thereof having a complementarity determining region (CDR) that specifically targets the tumor EpCAM antigen, which can effectively recognize tumor cells with positive EpCAM expression, and does not attack normal epithelial cells with low EpCAM expression.
Inventors:
WANG WEI (CN)
WEI YUQUAN (CN)
WEI YUQUAN (CN)
Application Number:
PCT/CN2021/123768
Publication Date:
March 30, 2023
Filing Date:
October 14, 2021
Export Citation:
Assignee:
UNIV SICHUAN (CN)
International Classes:
C07K19/00; A61K39/395; A61P35/00; C12N5/10
Foreign References:
| CN107602703A | 2018-01-19 | |||
| CN111333730A | 2020-06-26 | |||
| CN108484771A | 2018-09-04 | |||
| CN109694413A | 2019-04-30 | |||
| CN113166274A | 2021-07-23 | |||
| US20150329640A1 | 2015-11-19 | |||
| CN105384825A | 2016-03-09 |
Other References:
FU JUAN, SHANG YUHONG, QIAN ZHANG, HOU JINPING, YAN FENG, LIU GUODI, DEHUA LI, TIAN XIAOLI: "Chimeric Antigen receptor-T (CAR-T) cells targeting Epithelial cell adhesion molecule (EpCAM) can inhibit tumor growth in ovarian cancer mouse model", JOURNAL OF VETERINARY MEDICAL SCIENCE, JAPANESE SOCIETY OF VETERINARY SCIENCE, TOKYO., JP, vol. 83, no. 2, 1 January 2021 (2021-01-01), JP , pages 241 - 247, XP093054852, ISSN: 0916-7250, DOI: 10.1292/jvms.20-0455
Attorney, Agent or Firm:
CHONGQING ENZHOU INTELLECTUAL PROPERTY AGENCY (SPECIAL GENERAL PARTNERSHIP) (CN)
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