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Title:
ANTIBODY THAT SPECIFICALLY RECOGNIZES N TERMINUS OF APP669-x, AND IMMUNOASSAY METHOD
Document Type and Number:
WIPO Patent Application WO/2019/167830
Kind Code:
A1
Abstract:
Provided are: an antibody that recognizes peptides the N terminuses of which start from APP669 (collectively referred to as APP669-x) including the peptide APP669-711 related to amyloid β (Aβ); a method for measuring APP669-x using the antibody; and a sandwich immunoassay method capable of detecting and quantifying a polypeptide to be analyzed with high sensitivity. This APP669-x N terminus-recognizing monoclonal antibody specifically recognizes the N terminuses of APP669-x peptides. This immunoassay method uses the APP669-x N terminus-recognizing monoclonal antibody that specifically recognizes the N terminuses of APP669-x peptides, and comprises measuring APP669-x by reacting APP669-x in a sample with the APP669-x N terminus-recognizing monoclonal antibody.

Inventors:
KANEKO, Naoki (1 Nishinokyo-kuwabaracho, Nakagyo-ku, Kyoto-sh, Kyoto 11, 〒6048511, JP)
Application Number:
JP2019/006778
Publication Date:
September 06, 2019
Filing Date:
February 22, 2019
Export Citation:
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Assignee:
SHIMADZU CORPORATION (1 Nishinokyo-kuwabaracho, Nakagyo-ku Kyoto-sh, Kyoto 11, 〒6048511, JP)
International Classes:
C07K16/18; G01N33/531; G01N33/543
Domestic Patent References:
WO2015178398A12015-11-26
WO2007119685A12007-10-25
WO2017047529A12017-03-23
WO2012133452A12012-10-04
WO2008032712A12008-03-20
Foreign References:
JP2015511014A2015-04-13
JP2013513791A2013-04-22
JP2014533827A2014-12-15
JPH0694716A1994-04-08
JP2017508971A2017-03-30
Other References:
JOHNSON-WOOD, K. ET AL.: "Amyloid precursor protein processing and Abeta42 deposition in a transgenic mouse model of Alzheimer disease", PNAS, vol. 94, 1997, pages 1550 - 1555, XP002275435, doi:10.1073/pnas.94.4.1550
FUNAKOSHI: "Mouse monoclonal antibody that specifically recognizes N-terminal arginine, Anti- N-terminal Arginylation Antibody", 18 October 2017 (2017-10-18)
Attorney, Agent or Firm:
OKADA, Masahiro (OKADA & CO. 12th Shinko Bldg, 10F 1-6, Zaimoku-cho, Chuo-ku, Osaka-sh, Osaka 10, 〒5400010, JP)
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