ANTIBODY FOR TREATING AUTOIMMUNE DISEASE

WIPO Patent Application WO/2018/047894

A1

Provided is a novel antibody. According to the present invention, a monoclonal antibody or a binding fragment thereof binds to domain 3 of a human LAG-3, and has the properties described in (i) and (vi) and one or more of the properties described in (ii) to (v) below: (i) the antibody has in vitro ADCC activity; (ii) the antibody is a low-fucose antibody and reduces the number of LAG-3 positive cells in vivo; (iii) the antibody is a low-fucose antibody and suppresses experimental autoimmune encephalomyelitis in vivo; (iv) the human LAG-3 binds to a human activated T cell; (v) the human LAG-3 binds to a human major histocompatibility gene complex class II molecule in the presence of the antibody or a binding fragment thereof; and (vi) the human LAG-3 exhibits a human T cell suppression function in the presence of the antibody or a binding fragment thereof.

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MUKASA RYUTA (JP)
NAKAMURA KENSUKE (JP)
MURAMATSU SUMIE (JP)
MAKITA NAOYUKI (JP)

PCT/JP2017/032212

March 15, 2018

September 07, 2017

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DAIICHI SANKYO CO LTD (JP)

C12N15/09; A61K31/56; A61K39/395; A61K45/00; A61P1/04; A61P3/10; A61P5/16; A61P7/04; A61P7/06; A61P17/00; A61P17/06; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P27/02; A61P29/00; A61P31/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08

JP2010526052A	2010-07-29
JP2016516681A	2016-06-09

MATSUZAKI, JUNKO: "BASIC BIology and Clinical Application of LAG-3", THE MEDICAL FRONTLINE, vol. 70, no. 3, 2015, pages 36 (360) - 41 (365), XP009513842, ISSN: 0370-8241
AVICE, MARIE-NOELLE ET AL.: "Lymphocyte Activation Gene -3, a MHC Class II Ligand Expressed on Activated T Cells, Stimulates INF-alpha and IL -12 Production by Monocytes and Dendritic Cells", J. IMMUNOL., vol. 162, no. 5, 1999, pages 2748 - 2753, XP055497426

ISHIBASHI, Koki et al. (JP)

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