Title:
ANTIBODY FOR USE IN DETECTING EARLY-STAGE DAMAGE OF BLOOD BRAIN BARRIER DURING CEREBRAL ISCHEMIC STROKE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/128758
Kind Code:
A1
Abstract:
The present invention relates to the field of disease detection, and specifically discloses an antibody for detecting early-stage damage of the blood brain barrier during a cerebral ischemic stroke and an application thereof. The antibody is characterized in that said antibody only specifically recognizes DHYETDYTTGGESC in a degraded segment of occludin protein, and does not recognize occludin full length protein; therefore, the antibody may be used for specifically detecting early-stage damage of the blood brain barrier during a cerebral ischemic stroke, and the influence that the occludin full length protein in serum has on the detection result may be eliminated, thus obviously improving the specificity and accuracy of detecting early-stage damage of the blood brain barrier during a cerebral ischemic stroke.
Inventors:
QI ZHIFENG (CN)
LIU KE JIAN (CN)
JI XUNMING (CN)
LIU KE JIAN (CN)
JI XUNMING (CN)
Application Number:
PCT/CN2018/121503
Publication Date:
July 04, 2019
Filing Date:
December 17, 2018
Export Citation:
Assignee:
XUANWU HOSPITAL OF CAPITAL MEDICAL UNIV (CN)
International Classes:
G01N33/535; G01N33/558
Foreign References:
| CN108152492A | 2018-06-12 | |||
| CN105823887A | 2016-08-03 |
Other References:
BERTHA C. ELIAS ET AL.: "Phosphorylation of Tyr-398 and Tyr-402 in Occludin Prevents Its Interaction with ZO-1 and Destabilizes Its Assembly at the Tight Junctions", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 3, 16 January 2009 (2009-01-16), pages 1559 - 1569, XP055622442
Attorney, Agent or Firm:
BEIJING MIZAR STAR INTELLECTUAL PROPERTY AGENCY (CN)
Download PDF: