Title:
ANTIBODY WHICH SPECIFICALLY REACTS WITH HUMAN INTEGRIN A6B4
Document Type and Number:
WIPO Patent Application WO/2015/034052
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an anti-ITGA6/B4 human antibody which is capable of inhibiting the adhesion of cancer cells in a bone marrow niche, and significantly increasing the strength of the effect of an anti-cancer drug against an anticancer-drug-resistant strain, by specifically recognizing the ITGA6B4 complex expressed on a cell membrane, and inhibiting the adhesion of the ITGA6B4 complex and laminin to one another. The present invention provides an antibody to integrin A6B4 which specifically recognizes the human integrin A6B4 complex and inhibits intercellular adhesion.
Inventors:
MORISHITA KAZUHIRO (JP)
KANEDA KAZUKO (JP)
KUROSAWA YOSHIKAZU (JP)
KUROSAWA GENE (JP)
MITOMO KATSUYUKI (JP)
KOUDA KATSUSHI (JP)
UKAI YOSHINORI (JP)
KANEDA KAZUKO (JP)
KUROSAWA YOSHIKAZU (JP)
KUROSAWA GENE (JP)
MITOMO KATSUYUKI (JP)
KOUDA KATSUSHI (JP)
UKAI YOSHINORI (JP)
Application Number:
PCT/JP2014/073507
Publication Date:
March 12, 2015
Filing Date:
September 05, 2014
Export Citation:
Assignee:
UNIV MIYAZAKI (JP)
UNIV FUJITA HEALTH (JP)
PERSEUS PROTEOMICS INC (JP)
UNIV FUJITA HEALTH (JP)
PERSEUS PROTEOMICS INC (JP)
International Classes:
C12N15/09; A61K39/395; A61P1/00; A61P1/16; A61P1/18; A61P11/00; A61P13/08; A61P13/10; A61P15/00; A61P17/00; A61P35/00; A61P35/02; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Domestic Patent References:
| WO2008127655A1 | 2008-10-23 | |||
| WO2010098166A1 | 2010-09-02 | |||
| WO2010098166A1 | 2010-09-02 | |||
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Foreign References:
| JP4870348B2 | 2012-02-08 | |||
| US5530101A | 1996-06-25 | |||
| US5585089A | 1996-12-17 | |||
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| US5714350A | 1998-02-03 | |||
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| JP2005185281A | 2005-07-14 |
Other References:
YAMAKAWA, N. ET AL.: "The increased expression of integrin a6 (ITGA6) enhances drug resistance in EVI1high leukemia", PLOS ONE, vol. 7, no. 1, 2012, pages E30706, XP055324390
KUROSAWA, G. ET AL.: "Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic", PNAS, vol. 105, no. 20, 2008, pages 7287 - 7292, XP055324392
RABINOVITZ, I. ET AL.: "The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures", THE JOURNAL OF CELL BIOLOGY, vol. 139, no. 7, 1997, pages 1873 - 1884, XP001246668
See also references of EP 3042956A4
YAMAKAWA, N. ET AL.: "The Increased Expression of Integrin a6 (ITGA6) Enhances Drug Resistance in EVIlhi8h Leukemia", PROSONE, vol. 7, no. 1, 2012, pages E30706
MATSUNAGA, T. ET AL.: "Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia", NAT MED, vol. 9, 2003, pages 1158 - 65
KUROSAWA G ET AL.: "Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic", PROC NAT ACAD SCI USA, vol. 105, 2008, pages 7287 - 7292
WINTER ET AL., IMMUNOL. TODAY, vol. 14, 1993, pages 43 - 46
HASHIMOTO-GOTOH, T; MIZUNO, T; OGASAHARA, Y; DNA KAGAWA, M.: "An oligodeoxyribonucleotide-directed dual amber method for site-directed mutagenesis", GENE, vol. 152, 1995, pages 271 - 275
ZOLLER, MJ; SMITH, M.: "Oligonucleotide-directed mutagenesis of DNA fragments cloned into Ml 3 vectors", METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500
KRAMER, W; DRUTSA, V; JANSEN, H W; KRAMER, B; PFLUGFELDER, M; FRITZ, HJ: "The gapped duplex DNA approach to oligonucleotide-directed mutation construction", NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456
KRAMER W; FRITZ HJ: "Oligonucleotide-directed construction of mutations via gapped duplex DNA Methods", ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA: "Rapid and efficient site-specific mutagenesis without phenotypic selection", PROC NAML ACAD SCI USA, vol. 82, 1985, pages 488 - 492
KABAT, E. A. ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NIH PUBLICATION NO. 91-3242
A. WRIGHT; S. L. MORRISON, J. IMMUNOL., vol. 160, 1998, pages 3393 - 3402
K. MOTMANS ET AL., EUR. J. CANCER PREV., vol. 5, 1996, pages 512 - 5199
R P. JUNGHANS ET AL., CANCER RES., vol. 50, 1990, pages 1495 - 1502
R. W. MALONE ET AL., PROC. NAML. ACAD. SCI. USA, vol. 86, 1989, pages 6007
P. L. FEIGNER ET AL., PROC. NAML. ACAD. SCI. USA, vol. 84, 1987, pages 7413
F. L. GRAHAM; A. J. VAN DER EB, VIROLOGY, vol. 52, 1973, pages 456 - 467
OVAL ET AL., BLOOD, vol. 76, 1990, pages 1369 - 1374
TAETLE ET AL., CANCER RES., vol. 53, 1993, pages 3386 - 3393
HU ET AL., LEUKEMIA, vol. 10, 1996, pages 1025 - 1040
KUROSAWA, G. ET AL.: "Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic", PNAS, vol. 105, no. 20, 2008, pages 7287 - 7292, XP055324392
RABINOVITZ, I. ET AL.: "The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures", THE JOURNAL OF CELL BIOLOGY, vol. 139, no. 7, 1997, pages 1873 - 1884, XP001246668
See also references of EP 3042956A4
YAMAKAWA, N. ET AL.: "The Increased Expression of Integrin a6 (ITGA6) Enhances Drug Resistance in EVIlhi8h Leukemia", PROSONE, vol. 7, no. 1, 2012, pages E30706
MATSUNAGA, T. ET AL.: "Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia", NAT MED, vol. 9, 2003, pages 1158 - 65
KUROSAWA G ET AL.: "Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic", PROC NAT ACAD SCI USA, vol. 105, 2008, pages 7287 - 7292
WINTER ET AL., IMMUNOL. TODAY, vol. 14, 1993, pages 43 - 46
HASHIMOTO-GOTOH, T; MIZUNO, T; OGASAHARA, Y; DNA KAGAWA, M.: "An oligodeoxyribonucleotide-directed dual amber method for site-directed mutagenesis", GENE, vol. 152, 1995, pages 271 - 275
ZOLLER, MJ; SMITH, M.: "Oligonucleotide-directed mutagenesis of DNA fragments cloned into Ml 3 vectors", METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500
KRAMER, W; DRUTSA, V; JANSEN, H W; KRAMER, B; PFLUGFELDER, M; FRITZ, HJ: "The gapped duplex DNA approach to oligonucleotide-directed mutation construction", NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456
KRAMER W; FRITZ HJ: "Oligonucleotide-directed construction of mutations via gapped duplex DNA Methods", ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA: "Rapid and efficient site-specific mutagenesis without phenotypic selection", PROC NAML ACAD SCI USA, vol. 82, 1985, pages 488 - 492
KABAT, E. A. ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NIH PUBLICATION NO. 91-3242
A. WRIGHT; S. L. MORRISON, J. IMMUNOL., vol. 160, 1998, pages 3393 - 3402
K. MOTMANS ET AL., EUR. J. CANCER PREV., vol. 5, 1996, pages 512 - 5199
R P. JUNGHANS ET AL., CANCER RES., vol. 50, 1990, pages 1495 - 1502
R. W. MALONE ET AL., PROC. NAML. ACAD. SCI. USA, vol. 86, 1989, pages 6007
P. L. FEIGNER ET AL., PROC. NAML. ACAD. SCI. USA, vol. 84, 1987, pages 7413
F. L. GRAHAM; A. J. VAN DER EB, VIROLOGY, vol. 52, 1973, pages 456 - 467
OVAL ET AL., BLOOD, vol. 76, 1990, pages 1369 - 1374
TAETLE ET AL., CANCER RES., vol. 53, 1993, pages 3386 - 3393
HU ET AL., LEUKEMIA, vol. 10, 1996, pages 1025 - 1040
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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