Title:
ANTIBODY
Document Type and Number:
WIPO Patent Application WO2006066568
Kind Code:
A3
Abstract:
The invention relates to a CTLA-4-specific, agonistic, isolated monoclonal antibody which does not bond to the C''D loop of CTLA-4.
Inventors:
HANKE THOMAS (DE)
HORLING FRANK (DE)
TRISCHLER MARTIN (DE)
HORLING FRANK (DE)
TRISCHLER MARTIN (DE)
Application Number:
PCT/DE2005/002328
Publication Date:
August 31, 2006
Filing Date:
December 22, 2005
Export Citation:
Assignee:
TEGENERO AG (DE)
HANKE THOMAS (DE)
HORLING FRANK (DE)
TRISCHLER MARTIN (DE)
HANKE THOMAS (DE)
HORLING FRANK (DE)
TRISCHLER MARTIN (DE)
International Classes:
C07K16/28
Domestic Patent References:
| WO2004108158A1 | 2004-12-16 |
Other References:
THOMAS T C ET AL: "Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv", MOLECULAR IMMUNOLOGY, ELMSFORD, NY, US, vol. 33, no. 17-18, 1996, pages 1389 - 1401, XP002262113, ISSN: 0161-5890
GRIBBEN J G ET AL: "CTLA4 MEDIATES ANTIGEN-SPECIFIC APOPTOSIS OF HUMAN T CELLS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 92, 1995, pages 811 - 815, XP000604676, ISSN: 0027-8424
HWANG KWANG WOO ET AL: "Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 JUL 2002, vol. 169, no. 2, 15 July 2002 (2002-07-15), pages 633 - 637, XP009066946, ISSN: 0022-1767
GRIFFIN M D ET AL: "Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 MAY 2000, vol. 164, no. 9, 1 May 2000 (2000-05-01), pages 4433 - 4442, XP009066945, ISSN: 0022-1767
RILEY J L ET AL: "THE CD28 FAMILY: A T-CELL RHEOSTAT FOR THERAPEUTIC CONTROL OF T-CELL ACTIVATION", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 105, no. 1, 7 September 2004 (2004-09-07), pages 13 - 21, XP009047551, ISSN: 0006-4971
HOLT L J ET AL: "Domain antibodies: proteins for therapy", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 21, no. 11, November 2003 (2003-11-01), pages 484 - 490, XP004467495, ISSN: 0167-7799
DAVIES J ET AL: "Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding", IMMUNOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 2, no. 3, September 1996 (1996-09-01), pages 169 - 179, XP004070292, ISSN: 1380-2933
GRIBBEN J G ET AL: "CTLA4 MEDIATES ANTIGEN-SPECIFIC APOPTOSIS OF HUMAN T CELLS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 92, 1995, pages 811 - 815, XP000604676, ISSN: 0027-8424
HWANG KWANG WOO ET AL: "Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 JUL 2002, vol. 169, no. 2, 15 July 2002 (2002-07-15), pages 633 - 637, XP009066946, ISSN: 0022-1767
GRIFFIN M D ET AL: "Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 MAY 2000, vol. 164, no. 9, 1 May 2000 (2000-05-01), pages 4433 - 4442, XP009066945, ISSN: 0022-1767
RILEY J L ET AL: "THE CD28 FAMILY: A T-CELL RHEOSTAT FOR THERAPEUTIC CONTROL OF T-CELL ACTIVATION", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 105, no. 1, 7 September 2004 (2004-09-07), pages 13 - 21, XP009047551, ISSN: 0006-4971
HOLT L J ET AL: "Domain antibodies: proteins for therapy", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 21, no. 11, November 2003 (2003-11-01), pages 484 - 490, XP004467495, ISSN: 0167-7799
DAVIES J ET AL: "Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding", IMMUNOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 2, no. 3, September 1996 (1996-09-01), pages 169 - 179, XP004070292, ISSN: 1380-2933
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