Title:
ANTICANCER AGENT AND CARDIAC-FUNCTION-IMPROVING AGENT
Document Type and Number:
WIPO Patent Application WO/2023/090366
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an anticancer agent and/or a cardiac-function-improving agent having a novel action mechanism. A pharmaceutical composition containing, as an active ingredient, a substance that inhibits binding between a Kruppel-like factor 5 (KLF5) and a ubiquitin-specific peptidase 3 (USP3), in particular, any one of the compounds represented by formulas (I)-(III) or a pharmaceutically acceptable salt thereof, is useful as an anticancer agent and/or a cardiac-function-improving agent.
Inventors:
NAGAI RYOZO (JP)
NAKAYA TAKEO (JP)
AIZAWA KENICHI (JP)
KOUJI HIROYUKI (JP)
KASAI MASAJI (JP)
NAKANO HIROFUMI (JP)
NAKAYA TAKEO (JP)
AIZAWA KENICHI (JP)
KOUJI HIROYUKI (JP)
KASAI MASAJI (JP)
NAKANO HIROFUMI (JP)
Application Number:
PCT/JP2022/042585
Publication Date:
May 25, 2023
Filing Date:
November 16, 2022
Export Citation:
Assignee:
PRISM BIOLAB CO LTD (JP)
UNIV JICHI MEDICAL (JP)
UNIV JICHI MEDICAL (JP)
International Classes:
A61K45/00; A61K31/5395; A61P9/00; A61P9/04; A61P35/00; A61P43/00; C07D498/04; G01N33/15; G01N33/50
Domestic Patent References:
| WO2005010185A1 | 2005-02-03 |
Foreign References:
| JP2012505153A | 2012-03-01 |
Other References:
WU YINGYING, QIN JUNYING, LI FUBING, YANG CHUANYU, LI ZHEN, ZHOU ZHONGMEI, ZHANG HAILIN, LI YUNXI, WANG XINYE, LIU RONG, TAO QIAN,: "USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 294, no. 47, 1 November 2019 (2019-11-01), US , pages 17837 - 17847, XP093068392, ISSN: 0021-9258, DOI: 10.1074/jbc.RA119.009102
NAKAYA TAKEO, AIZAWA KENICHI, TAGUCHI YUKI, TSUJI KENTARO, SEKINE SACHI, MURAKAMI KAZUHIRO, KASAI MASAJI, NAKANO HIROFUMI, KONDOH : "Development of Low-Molecular-Weight Compounds Targeting the Cancer-Associated KLF5 Transcription Factor", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 4, 14 April 2022 (2022-04-14), US , pages 687 - 694, XP093068394, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.1c00721
NAKAYA TAKEO, AIZAWA KENICHI, TAGUCHI YUKI, TSUJI KENTARO, SEKINE SACHI, MURAKAMI KAZUHIRO, KASAI MASAJI, NAKANO HIROFUMI, KONDOH : "Development of Low-Molecular-Weight Compounds Targeting the Cancer-Associated KLF5 Transcription Factor", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 4, 14 April 2022 (2022-04-14), US , pages 687 - 694, XP093068394, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.1c00721
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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