Title:
ANTICANCER AGENT
Document Type and Number:
WIPO Patent Application WO/2013/133253
Kind Code:
A1
Abstract:
The present invention provides an anticancer agent for which an active ingredient is a human antibody light chain exhibiting cytotoxicity against cancer cells, in particular lung cancer cells. This anticancer agent is characterized by primarily containing either: a human antibody κ-type light chain that is a dimer and comprises a polypeptide in which a variable region is represented by an amino acid sequence of SEQ ID NO: 1, 9, or 13, or by an amino acid sequence obtained when one or a plurality of amino acids are substituted, added, or deleted within those amino acid sequences; or a human antibody κ-type light chain that is a monomer and comprises a polypeptide in which a variable region is represented by an amino acid sequence of SEQ ID NO: 19 or by an amino acid sequence obtained when one or a plurality of amino acids are substituted, added, or deleted within that amino acid sequence.
Inventors:
UDA TAIZO (JP)
HIFUMI EMI (JP)
HIFUMI EMI (JP)
Application Number:
PCT/JP2013/055927
Publication Date:
September 12, 2013
Filing Date:
March 05, 2013
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
International Classes:
A61K39/395; A61P11/00; A61P35/00; C07K16/18; C12N15/09
Domestic Patent References:
| WO2011102517A1 | 2011-08-25 | |||
| WO2008029807A1 | 2008-03-13 |
Foreign References:
| JP2006197930A | 2006-08-03 | |||
| JP2006501856A | 2006-01-19 | |||
| JP2005508176A | 2005-03-31 | |||
| JP2011526480A | 2011-10-13 | |||
| JP2006197930A | 2006-08-03 |
Other References:
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING CO.
ROOPENIAN , D. C. ET AL., NAT. REV. IMMUNOL., vol. 7, 2007, pages 715 - 725
ROOPENIAN , D. C. ET AL., NAT. REV. IMMUNOL., vol. 7, 2007, pages 715 - 725
Attorney, Agent or Firm:
SHIGA Masatake et al. (JP)
Masatake Shiga (JP)
Masatake Shiga (JP)
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Claims: