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Patent Searching and Data


Title:
ANTICANCER AGENT
Document Type and Number:
WIPO Patent Application WO/2019/151320
Kind Code:
A1
Abstract:
The problem addressed by the present invention is to provide a technique for improving the anticancer effect of ubenimex, especially the anticancer effect on solid cancers. The problem is solved by a compound containing a chain-form structure obtained by linking a plurality of ubenimex to a chain-form polymer.

Inventors:
MORI, Masaki (1-1 Yamadaoka, Suita-sh, Osaka 71, 〒5650871, JP)
ISHII, Hideshi (1-1 Yamadaoka, Suita-sh, Osaka 71, 〒5650871, JP)
KONNO, Masamitsu (1-1 Yamadaoka, Suita-sh, Osaka 71, 〒5650871, JP)
EGUCHI, Hidetoshi (1-1 Yamadaoka, Suita-sh, Osaka 71, 〒5650871, JP)
HARAGUCHI, Naotsugu (1-1 Yamadaoka, Suita-sh, Osaka 71, 〒5650871, JP)
TOSHIYAMA, Reishi (1-1 Yamadaoka, Suita-sh, Osaka 71, 〒5650871, JP)
NISHIYAMA, Nobuhiro (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
TAKEMOTO, Hiroyasu (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
Application Number:
JP2019/003150
Publication Date:
August 08, 2019
Filing Date:
January 30, 2019
Export Citation:
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Assignee:
OSAKA UNIVERSITY (1-1 Yamadaoka, Suita-shi Osaka, 71, 〒5650871, JP)
TOKYO INSTITUTE OF TECHNOLOGY (2-12-1, Ookayama Meguro-k, Tokyo 50, 〒1528550, JP)
International Classes:
C07K19/00; A61K31/198; A61K31/785; A61K45/00; A61K47/34; A61K47/42; A61K47/60; A61K47/64; A61P35/00; A61P43/00; C07K5/06; C07K14/81; C12N9/99; C12N9/64
Foreign References:
JP2002515418A2002-05-28
JP2017105800A2017-06-15
Other References:
YAMASHITA, MASAFUMI ET AL.: "A CD 13 inhibitor, ubenimex, synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 49, 2016, pages 89 - 98, XP055628479
ZHOU, ZHUXIAN ET AL.: "A multifunctional PEG-PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery", JOURNAL OF MATERIALS CHEMISTRY B, vol. 3, 2015, pages 7594 - 7603, XP055628483
TOSHIYAMA, REISHI ET AL.: "Poly(ethylene glycol)- poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells", ONCOGENE, vol. 38, no. 2, August 2018 (2018-08-01), pages 244 - 260, XP036668959
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (Kitahama TNK Building, 1-7-1 Doshomachi, Chuo-ku, Osaka-sh, Osaka 45, 〒5410045, JP)
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