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Title:
ANTICANCER AGENT
Document Type and Number:
WIPO Patent Application WO/2019/163684
Kind Code:
A1
Abstract:
Provided is an anticancer agent that has a novel function based on a novel mechanism. Also provided is a novel anticancer agent that has a function of suppressing cancer stem cell properties and/or a function of suppressing cancer cell proliferation. Also provided is a method for screening a novel anticancer agent. The anticancer agent comprises as an active ingredient a substance having an anti-adipsin function. The anticancer agent according to the present invention, which comprises as an active ingredient a substance having an anti-adipsin function, has functions of suppressing cancer stem cell properties and suppressing cancer cell proliferation. The antitumor function based on the suppression of adipsin is a novel mechanism. Therefore, a novel anticancer agent can be screened by focusing on this function mechanism. Thus, a more efficacious anticancer agent capable of suppressing cancer stem cell properties can be acquired.

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Inventors:
SHIMONO YOHEI (JP)
GOTO HIDEAKI (JP)
MINAMI HIRONOBU (JP)
Application Number:
PCT/JP2019/005695
Publication Date:
August 29, 2019
Filing Date:
February 15, 2019
Export Citation:
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Assignee:
UNIV KOBE NAT UNIV CORP (JP)
FUJITA ACAD (JP)
International Classes:
A61K45/00; A61P35/00; A61P35/04; A61P43/00; C12Q1/02; C12Q1/37; G01N33/15; G01N33/50
Domestic Patent References:
WO2007141004A12007-12-13
WO2009105217A22009-08-27
Foreign References:
US20170160291A12017-06-08
Other References:
PATTRICK, M. ET AL.: "Dual role of complement in adipose tissue", MOLECULAR IMMUNOLOGY, vol. 46, 2009, pages 755 - 760, XP025912802, ISSN: 0161-5890
GOTO, H. ET AL.: "Adipose-derived stem cells enhance human breast cancer growth and cancer stem cell -like properties through adipsin", ONCOGENE, vol. 38, no. 6, 7 February 2019 (2019-02-07), pages 767 - 779, XP036695894, ISSN: 1476-5594
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
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