Title:
ANTICANCER DRUG COMPRISING CYCLIC RGD SEQUENCE-CONTAINING PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2014/084378
Kind Code:
A1
Abstract:
Provided is an anticancer drug which has advantages such as reduced gastrointestinal toxicity and less weight loss in patients. This anticancer drug comprises an anti-cancer active ingredient and a cyclic arginine-glycine-aspartic acid (RGD) sequence-containing peptide.
Inventors:
KATAOKA KAZUNORI (JP)
NISHIYAMA NOBUHIRO (JP)
MIURA YUTAKA (JP)
NISHIYAMA NOBUHIRO (JP)
MIURA YUTAKA (JP)
Application Number:
PCT/JP2013/082272
Publication Date:
June 05, 2014
Filing Date:
November 29, 2013
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61K45/00; A61K31/282; A61K33/243; A61K38/00; A61K47/34; A61K47/42; A61K47/48; A61P35/00; C07K7/06
Other References:
DANHIER F ET AL.: "RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis", MOL PHARM, vol. 9, no. 11, pages 2961 - 2973
CABRAL H ET AL.: "Optimization of (1,2-diamino-cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity", J CONTROL RELEASE, vol. 121, no. 3, 2007, pages 146 - 155
ZHAN C ET AL.: "Cyclic RGD conjugated poly (ethylene glycol)-co-poly(lactic acid) micelle enhances paclitaxel anti-glioblastoma effect", J CONTROL RELEASE, vol. 143, no. 1, April 2010 (2010-04-01), pages 136 - 142
CABRAL H ET AL.: "Preparation and biological properties of dichloro(1,2-diaminocyclohexane) platinum(II) (DACHPt)-loaded polymeric micelles.", J CONTROL RELEASE, vol. 101, 2005, pages 223 - 232
ZHAN C ET AL.: "Co-delivery of TRAIL gene enhances the anti-glioblastoma effect of paclitaxel in vitro and in vivo", J CONTROL RELEASE, vol. 160, no. 3, pages 630 - 636
CABRAL H ET AL.: "Optimization of (1,2-diamino-cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity", J CONTROL RELEASE, vol. 121, no. 3, 2007, pages 146 - 155
ZHAN C ET AL.: "Cyclic RGD conjugated poly (ethylene glycol)-co-poly(lactic acid) micelle enhances paclitaxel anti-glioblastoma effect", J CONTROL RELEASE, vol. 143, no. 1, April 2010 (2010-04-01), pages 136 - 142
CABRAL H ET AL.: "Preparation and biological properties of dichloro(1,2-diaminocyclohexane) platinum(II) (DACHPt)-loaded polymeric micelles.", J CONTROL RELEASE, vol. 101, 2005, pages 223 - 232
ZHAN C ET AL.: "Co-delivery of TRAIL gene enhances the anti-glioblastoma effect of paclitaxel in vitro and in vivo", J CONTROL RELEASE, vol. 160, no. 3, pages 630 - 636
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Aoki 篤 (JP)
Aoki 篤 (JP)
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