Title:
ANTICANCER DRUG
Document Type and Number:
WIPO Patent Application WO/2014/196621
Kind Code:
A1
Abstract:
An anticancer drug and a cancer cell death inducing agent which comprises, as an active ingredient, an inositol phospholipid compound, in particular, 1,2-O-bis-[8-{2-(2-pentyl- cyclopropylmethyl)-cyclopropyl}-octanoyl]-sn-glycero-3- phosphatidyl-inositol.
Inventors:
NISHIZAKI TOMOYUKI (JP)
NAKANO TAKASHI (JP)
TANAKA AKITO (JP)
SHIMIZU TADASHI (JP)
KANNO TAKESHI (JP)
NAKANO TAKASHI (JP)
TANAKA AKITO (JP)
SHIMIZU TADASHI (JP)
KANNO TAKESHI (JP)
Application Number:
PCT/JP2014/065042
Publication Date:
December 11, 2014
Filing Date:
June 06, 2014
Export Citation:
Assignee:
KTN BIOTEC INC (JP)
International Classes:
A61K31/683; A61P35/00; A61P43/00
Domestic Patent References:
| WO2002028399A1 | 2002-04-11 | |||
| WO2002050013A1 | 2002-06-27 |
Foreign References:
| JPS63250323A | 1988-10-18 | |||
| JP2007210967A | 2007-08-23 | |||
| JP2005247728A | 2005-09-15 |
Other References:
KANNO T: "Effects of newly synthesized DCP-LA- phospholipids on protein kinase C and protein phosphatases", CELL PHYSIOL BIOCHEM, vol. 31, no. 4-5, 5 April 2013 (2013-04-05), pages 555 - 564, XP 008180413, DOI: doi:10.1159/000350076
COMBS AP: "Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer", J MED CHEM, vol. 53, no. 6, 2010, pages 2333 - 2344, XP 055173028, DOI: doi:10.1021/jm901090b
PERROTTI D: "Protein phosphatase 2A: a target for anticancer therapy", LANCET ONCOL, vol. 14, no. 6, May 2013 (2013-05-01), pages 229 - 238, XP055301035
TSUCHIYA A: "A novel PP2A enhancer induces caspase-independent apoptosis of MKN28 gastric cancer cells with high MEK activity", CANCER LETTERS, vol. 347, May 2014 (2014-05-01), pages 123 - 128, XP 055275691, DOI: doi:10.1016/j.canlet.2014.01.034
See also references of EP 3006033A4
YAGUCHI T; NAGATA T; NISHIZAKI T.: "Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha-7 nicotinic ACh receptors", LIFE SCI, vol. 84, 2009, pages 263 - 6, XP055174884, DOI: doi:10.1016/j.lfs.2008.12.003
YAGUCHI T; NAGATA T; NISHIZAKI T: "1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine improves cognitive decline by enhancing long-term depression", BEHAV BRAIN RES, vol. 204, 2009, pages 129 - 32, XP026422139
THE CHEMICAL SOCIETY OF JAPAN: "Jikken Kagaku Kouza 16, synthesis of organic compound (kyo); carboxylic acid·amino acid.peptide,", article "chapter 3: phosphate"
COMBS AP: "Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer", J MED CHEM, vol. 53, no. 6, 2010, pages 2333 - 2344, XP 055173028, DOI: doi:10.1021/jm901090b
PERROTTI D: "Protein phosphatase 2A: a target for anticancer therapy", LANCET ONCOL, vol. 14, no. 6, May 2013 (2013-05-01), pages 229 - 238, XP055301035
TSUCHIYA A: "A novel PP2A enhancer induces caspase-independent apoptosis of MKN28 gastric cancer cells with high MEK activity", CANCER LETTERS, vol. 347, May 2014 (2014-05-01), pages 123 - 128, XP 055275691, DOI: doi:10.1016/j.canlet.2014.01.034
See also references of EP 3006033A4
YAGUCHI T; NAGATA T; NISHIZAKI T.: "Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha-7 nicotinic ACh receptors", LIFE SCI, vol. 84, 2009, pages 263 - 6, XP055174884, DOI: doi:10.1016/j.lfs.2008.12.003
YAGUCHI T; NAGATA T; NISHIZAKI T: "1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine improves cognitive decline by enhancing long-term depression", BEHAV BRAIN RES, vol. 204, 2009, pages 129 - 32, XP026422139
THE CHEMICAL SOCIETY OF JAPAN: "Jikken Kagaku Kouza 16, synthesis of organic compound (kyo); carboxylic acid·amino acid.peptide,", article "chapter 3: phosphate"
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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