Title:
ANTICANCER THERAPEUTIC ADJUVANT CONTAINING PROTEIN HAVING LACTOFERRIN ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2018/079701
Kind Code:
A1
Abstract:
The present invention pertains to an anticancer therapeutic adjuvant which contains a protein having lactoferrin activity and which is intended for concomitant use with a platinum-based anticancer drug composition, enhances anticancer activity of said composition, and reduces pain derived from said composition. This protein having lactoferrin activity provides a disease preventive or therapeutic agent that is intended for concomitant use with a platinum-based anticancer drug, that is useful in reducing pain derived from a platinum-based anticancer drug composition, and that further enhances anticancer activity.
Inventors:
TAKEUCHI TAKASHI (JP)
KAGAYA SHINJI (JP)
HOSHINO TATSUO (JP)
KAGAYA SHINJI (JP)
HOSHINO TATSUO (JP)
Application Number:
PCT/JP2017/038865
Publication Date:
May 03, 2018
Filing Date:
October 27, 2017
Export Citation:
Assignee:
NRL PHARMA INC (JP)
NAT UNIV CORP TOTTORI UNIV (JP)
NAT UNIV CORP TOTTORI UNIV (JP)
International Classes:
A61K38/40; A61K31/282; A61K33/243; A61P35/00
Domestic Patent References:
| WO2003061688A1 | 2003-07-31 | |||
| WO2013162050A1 | 2013-10-31 |
Foreign References:
| JP2005533029A | 2005-11-04 | |||
| JP2012502996A | 2012-02-02 | |||
| JP2005263762A | 2005-09-29 | |||
| BR102012006624A2 | 2013-11-19 |
Other References:
DIGUMARTI R. ET AL.: "A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Oral Talactoferrin in Combination with Carboplatin and Paclitaxel in Previously Untreated Locally Advanced or Metastatic Non-small Cell Lung Cancer", J. THORAC. ONCOL., vol. 6, no. 6, 2011, pages 1098 - 1103, XP055606570
ONAL, A. ET AL.: "Effect of Prolonged administration of bovine lactoferrin in neuropathic pain: Involvement of opioid receptors, nitric oxide and TNF-alpha", LIFE SCI., vol. 86, no. 7-8, 2010, pages 251 - 259, XP026883899, DOI: doi:10.1016/j.lfs.2009.12.007
HARADA, ETSUMORI: "Transportation Dynamics of Milk-derived Lactoferin and Its Novel Function-Anti-Stress, Anti-nociceptive, and anti-inframmative Actions", CHRONIC PAIN, vol. 23, no. 1, 2004, pages 9 - 23
EGASHIRA, NOBUAKI ET AL.,: "The current state of the drugs for the treatment of peripheral neuropathy induced by anticancer drugs", JOURNAL OF THE JAPANESE PHARMACOLOGICAL SOCIETY, vol. 136, no. 5, 2010, pages 275 - 279, XP008175707
ONAL, A. ET AL.: "Effect of Prolonged administration of bovine lactoferrin in neuropathic pain: Involvement of opioid receptors, nitric oxide and TNF-alpha", LIFE SCI., vol. 86, no. 7-8, 2010, pages 251 - 259, XP026883899, DOI: doi:10.1016/j.lfs.2009.12.007
HARADA, ETSUMORI: "Transportation Dynamics of Milk-derived Lactoferin and Its Novel Function-Anti-Stress, Anti-nociceptive, and anti-inframmative Actions", CHRONIC PAIN, vol. 23, no. 1, 2004, pages 9 - 23
EGASHIRA, NOBUAKI ET AL.,: "The current state of the drugs for the treatment of peripheral neuropathy induced by anticancer drugs", JOURNAL OF THE JAPANESE PHARMACOLOGICAL SOCIETY, vol. 136, no. 5, 2010, pages 275 - 279, XP008175707
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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