Title:
ANTICARIES COMPOSITIONS AND PROBIOTICS/PREBIOTICS
Document Type and Number:
WIPO Patent Application WO/2012/028759
Kind Code:
A3
Abstract:
The present invention relates to various specific bacterial strains isolated from individuals without caries, and characterized in that the strains have an inhibitory activity against cariogenic organisms. The invention also relates to a method for isolating said strains, as well as bioactive peptides, i.e. antimicrobial peptides of human and bacterial origin which also exhibit anticaries activity. The invention additionally relates to pharmaceutical compositions and/or probiotics/prebiotics, functional foods, mouthwashes, toothpaste, chewing gum, etc. that include at least one of the strains and/or at least one of the bioactive peptides of the invention or a combination thereof, and which are useful in the treatment and/or prevention of infectious diseases of the oral cavity, preferably caries.
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Inventors:
MIRA OBRADOR ALEJANDRO (ES)
Application Number:
PCT/ES2011/070609
Publication Date:
August 02, 2012
Filing Date:
August 31, 2011
Export Citation:
Assignee:
CT SUPERIOR DE INVESTIGACION EN SALUD PUBLICA CSISP (ES)
MIRA OBRADOR ALEJANDRO (ES)
MIRA OBRADOR ALEJANDRO (ES)
International Classes:
C12N1/20; A61K35/744; C07K14/195; C07K14/47; A61K38/16
Domestic Patent References:
| WO2003070919A1 | 2003-08-28 | |||
| WO2004072093A2 | 2004-08-26 |
Foreign References:
| JP2002000261A | 2002-01-08 |
Other References:
JEFFREY D. HILLMAN: "Genetically modified Streptococcus mutans for the prevention of dental caries", ANTONIE VAN LEEUWENHOEK, vol. 82, no. 1/4, 1 January 2002 (2002-01-01), pages 361 - 366, XP055016360, ISSN: 0003-6072, DOI: 10.1023/A:1020695902160
LOESCHE W J: "Role of Streptococcus mutans in human dental decay", MICROBIOLOGICAL REVIEWS, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 50, no. 4, 1 December 1986 (1986-12-01), pages 353 - 380, XP002492130, ISSN: 0146-0749
MONTVILLE T J ET AL: "Mechanistic action of pediocin and nisin: Recent progress and unresolved questions", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 50, no. 5, November 1998 (1998-11-01), pages 511 - 519, XP002676546, ISSN: 0175-7598
KOMATSUZAWA HITOSHI ET AL: "Susceptibility of periodontopathogenic and cariogenic bacteria to Defensins and potential therapeutic use of Defensins in oral diseases", CURRENT PHARMACEUTICAL DESIGN, vol. 13, no. 30, 2007, pages 3084 - 3095, XP002676547, ISSN: 1381-6128
LOESCHE W J: "Role of Streptococcus mutans in human dental decay", MICROBIOLOGICAL REVIEWS, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 50, no. 4, 1 December 1986 (1986-12-01), pages 353 - 380, XP002492130, ISSN: 0146-0749
MONTVILLE T J ET AL: "Mechanistic action of pediocin and nisin: Recent progress and unresolved questions", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 50, no. 5, November 1998 (1998-11-01), pages 511 - 519, XP002676546, ISSN: 0175-7598
KOMATSUZAWA HITOSHI ET AL: "Susceptibility of periodontopathogenic and cariogenic bacteria to Defensins and potential therapeutic use of Defensins in oral diseases", CURRENT PHARMACEUTICAL DESIGN, vol. 13, no. 30, 2007, pages 3084 - 3095, XP002676547, ISSN: 1381-6128
Attorney, Agent or Firm:
ILLESCAS TABOADA, Manuel (13 5ยบ Izda, Madrid, ES)
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