Title:
ANTIFUNGAL SOLUTION, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/041083
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of medicine, and particularly relates to an antifungal solution, a preparation method therefor, and use thereof. The present invention provides an antifungal solution. Raw materials for preparation comprise an antifungal medicament and a solvent; the mass ratio of the antifungal medicament to the solvent is (0.1-1):(18-318); the solvent comprises an ionic liquid, an alcohol organic solvent, and water. In the present invention, the ionic liquid has excellent dissolving capacity, skin permeability-promoting performance, and antifungal effect; the water can destroy the polar network of the original ionic liquid to form smaller soluble ionic groups, so that miscibility windows are greatly increased; the alcohol organic solvent can form a latent solvent with the ionic liquid and the water, thereby facilitating miscibility. The antifungal solution provided in the present invention can ensure that the medicament in the system is kept in a dissolved state, so that the bioavailability is improved, and it can be ensured that a better treatment effect can be obtained when the dose is reduced.
Inventors:
WU XIYING (CN)
ZHU QUANGANG (CN)
CHEN ZHONGJIAN (CN)
SHEN MIN (CN)
TAI ZONGGUANG (CN)
YU QIN (CN)
QI JIANPING (CN)
WU WEI (CN)
ZHU QUANGANG (CN)
CHEN ZHONGJIAN (CN)
SHEN MIN (CN)
TAI ZONGGUANG (CN)
YU QIN (CN)
QI JIANPING (CN)
WU WEI (CN)
Application Number:
PCT/CN2023/098300
Publication Date:
February 29, 2024
Filing Date:
June 05, 2023
Export Citation:
Assignee:
SHANGHAI SKIN DISEASE HOSPITAL (CN)
International Classes:
A61K45/00; A61K9/08; A61K31/4174; A61K47/18
Foreign References:
| CN115671285A | 2023-02-03 | |||
| US20210353565A1 | 2021-11-18 | |||
| EP0396184A2 | 1990-11-07 |
Other References:
WU, XIYING ET AL.: "Ionic Liquids Containing Ketoconazole Improving Topical Treatment of T. Interdigitale Infection by Synergistic Action", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 589, 3 September 2020 (2020-09-03), XP086309104, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2020.119842
LI, XIAODAN ET AL.: "Applications of Choline-Based Ionic Liquids in Drug Delivery", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 612, 9 December 2021 (2021-12-09), XP086907053, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2021.121366
LI, XIAODAN ET AL.: "Applications of Choline-Based Ionic Liquids in Drug Delivery", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 612, 9 December 2021 (2021-12-09), XP086907053, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2021.121366
Attorney, Agent or Firm:
SHANGHAI TECHNOVO INTELLECTUAL PROPERTY AGENT FIRM (CN)
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