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Title:
ANTIGEN ARRAYS PRESENTING IL-5, IL-3 OR EOTAXIN FOR TREATMENT OF ALLERGIC EOSINOPHILIC DISEASES
Document Type and Number:
WIPO Patent Application WO2003040164
Kind Code:
A3
Abstract:
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an array comprising a protein or peptide of IL-5, IL-13 or eotaxin. More specifically, the invention provides a composition comprising a virus-like particle and at least one protein, or peptide of IL-5, IL-13 and/or eotaxin bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of allergic diseases with an eosinophilic component and as a pharmaccine to prevent or cure allergic diseases with an eosinophilic component and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

Inventors:
BACHMANN MARTIN (CH)
JENNINGS GARY (CH)
SONDEREGGER IVO (CH)
Application Number:
PCT/EP2002/012455
Publication Date:
October 23, 2003
Filing Date:
November 07, 2002
Export Citation:
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Assignee:
CYTOS BIOTECHNOLOGY AG (CH)
BACHMANN MARTIN (CH)
JENNINGS GARY (CH)
SONDEREGGER IVO (CH)
International Classes:
C12N15/09; A61K39/00; A61K39/12; A61K39/35; A61K39/39; A61K47/48; A61P11/06; A61P25/28; A61P35/00; A61P37/08; C07K14/005; C07K14/01; C07K14/02; C07K14/08; C07K14/47; C07K14/52; C07K14/54; C07K16/00; C07K16/08; C07K16/22; C07K16/28; C07K16/40; C07K16/42; C07K19/00; C12N7/00; C12N7/01; A61K38/095; (IPC1-7): A61K39/39; A61K39/385; A61K38/19; A61P11/06; A61K39/12; C07K14/54; C07K14/52
Domestic Patent References:
WO2000065058A12000-11-02
WO2000023955A12000-04-27
WO2000032227A22000-06-08
Other References:
HERTZ M ET AL: "Active vaccination against IL-5 bypasses immunological tolerance and ameliorates experimental asthma.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD.: 1950) UNITED STATES 1 OCT 2001, vol. 167, no. 7, 1 October 2001 (2001-10-01), pages 3792 - 3799, XP002250682, ISSN: 0022-1767
CHACKERIAN B ET AL: "Induction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, no. 5, 2 March 1999 (1999-03-02), pages 2373 - 2378, XP002133522, ISSN: 0027-8424
KOLETZKI D ET AL: "MOSAIC HEPATITIS B VIRUS CORE PARTICLES ALLOW INSERTION OF EXTENDED FOREIGN PROTEIN SEGMENTS", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, READING, GB, vol. 78, 1997, pages 2049 - 2053, XP002920336, ISSN: 0022-1317
BORISOVA G P ET AL: "RECOMBINANT CORE PARTICLES OF HEPATITIS B VIRUS EXPOSING FOREIGN ANTIGENIC DETERMINANTS ON THEIR SURFACE", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 259, no. 1, 1 December 1989 (1989-12-01), pages 121 - 124, XP002035980, ISSN: 0014-5793
GUO REN-FENG ET AL: "Eotaxin expression in Sephadex-induced lung injury in rats.", AMERICAN JOURNAL OF PATHOLOGY, vol. 155, no. 6, December 1999 (1999-12-01), pages 2001 - 2008, XP002250683, ISSN: 0002-9440
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