Title:
ANTIGEN-BINDING MOLECULES WITH IMPROVED CYTOSOL-PENETRATING ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2022/138692
Kind Code:
A1
Abstract:
The present invention provides an antigen-binding molecule (e.g. antibody) with improved cytosol-penetrating ability, the molecule comprising an amino acid substitutions on at least one selected from the group consisting of CDRL1, CDRL2 and CDRL3 in a light-chain variable region, or an antigen-binding fragment (antibody fragment) thereof; and pharmaceutical compositions comprising the antigen-binding molecule; methods for delivering the antigen-binding molecule specifically into the cytosol of a target cell; methods of removing, suppressing, or activating a cytosolic antigen in a target cell-specific manner by using the antigen-binding molecule; and pharmaceutical compositions for diagnosing, preventing, or treating a disease in a subject comprising the antigen-binding molecule.
Inventors:
IKAWA YURI (JP)
SAVORY NASA (SG)
SAVORY NASA (SG)
Application Number:
PCT/JP2021/047478
Publication Date:
June 30, 2022
Filing Date:
December 22, 2021
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C12N15/13; A61K39/395; A61P43/00; C07K16/00; C07K16/46; C07K19/00; C12N15/62
Domestic Patent References:
| WO2020149613A1 | 2020-07-23 | |||
| WO2020022262A1 | 2020-01-30 |
Foreign References:
| US20190144566A1 | 2019-05-16 |
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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