Title:
ANTIGEN-BINDING PROTEIN TARGETING CD70 AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/116952
Kind Code:
A1
Abstract:
An antigen-binding protein targeting CD70. In particular, the present invention relates to a chimeric antigen receptor containing the antigen binding protein and the use thereof, and cells containing or expressing the antigen binding protein. The antigen-binding protein binds to a CD70 protein at 1 nM of a KD value. The chimeric antigen receptor containing the antigen-binding protein has strong specific recognition and binding abilities to the CD70 protein. The cells containing or expressing the antigen-binding protein can secrete cytokines IL-2 and IFN-γ.
Inventors:
WANG WENBO (CN)
LIN YANNI (CN)
LIN YANNI (CN)
Application Number:
PCT/CN2021/134248
Publication Date:
June 09, 2022
Filing Date:
November 30, 2021
Export Citation:
Assignee:
CURE GENETICS CO LTD (CN)
International Classes:
C07K19/00; A61K35/17; C12N5/10; C12N15/62
Domestic Patent References:
| WO2015156673A1 | 2015-10-15 | |||
| WO2018152181A1 | 2018-08-23 | |||
| WO2013154760A1 | 2013-10-17 | |||
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Foreign References:
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Other References:
YANG MEIJIA, TANG XIN, ZHANG ZONGLIANG, GU LEI, WEI HENG, ZHAO SHASHA, ZHONG KUNHONG, MU MIN, HUANG CHENG, JIANG CAIYING, XU JIANG: "Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors", THERANOSTICS, vol. 10, no. 17, 1 January 2020 (2020-01-01), AU , pages 7622 - 7634, XP055937499, ISSN: 1838-7640, DOI: 10.7150/thno.43991
KANG, XIAOZHEN ET AL., CHINESE JOURNAL OF BIOTECHNOLOGY, vol. 34, no. 12, 2018, pages 1974 - 1984
"GenBank", Database accession no. NM_001252.5
"UniProt", Database accession no. P32970
SADELAIN MBRENTJENS RRIVI 'ERE I: "The basicprinciples of chimeric antigen receptor design", CANCER DISCOV., vol. 3, no. 4, 2013, pages 388 - 398
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DOTTI GGOTTSCHALK SSAVOLDO BBRENNER MK: "Design and development of therapies using chimeric antigen receptor-expressing T cells", IMMUNOL REV., vol. 257, no. 1, 2014, pages 107 - 126, XP055552726, DOI: 10.1111/imr.12131
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC.NATL.ACAD.SCI., vol. 85, 1988, pages 5879 - 5883
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY
FREIREICH ET AL., CANCER CHEMOTHER. REP., vol. 50, 1966, pages 219
"Scientific Tables, Geigy Pharmaceuticals", 1970, ARDSLEY, pages: 537
KANG, XIAOZHEN ET AL., CHINESE JOURNAL OF BIOTECHNOLOGY, vol. 34, no. 12, 2018, pages 1974 - 1984
"GenBank", Database accession no. NM_001252.5
"UniProt", Database accession no. P32970
SADELAIN MBRENTJENS RRIVI 'ERE I: "The basicprinciples of chimeric antigen receptor design", CANCER DISCOV., vol. 3, no. 4, 2013, pages 388 - 398
TURTLE CJHUDECEK MJENSEN MCRIDDELL SR: "Engineered T cells for anti-cancer therapy", CURR OPIN IMMUNOL., vol. 24, no. 5, 2012, pages 633 - 639, XP055272888, DOI: 10.1016/j.coi.2012.06.004
DOTTI GGOTTSCHALK SSAVOLDO BBRENNER MK: "Design and development of therapies using chimeric antigen receptor-expressing T cells", IMMUNOL REV., vol. 257, no. 1, 2014, pages 107 - 126, XP055552726, DOI: 10.1111/imr.12131
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC.NATL.ACAD.SCI., vol. 85, 1988, pages 5879 - 5883
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY
FREIREICH ET AL., CANCER CHEMOTHER. REP., vol. 50, 1966, pages 219
"Scientific Tables, Geigy Pharmaceuticals", 1970, ARDSLEY, pages: 537
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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