Title:
ANTIGEN-BINDING PROTEIN TARGETING STREPTOCOCCUS PNEUMONIAE HEMOLYSIN PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/199527
Kind Code:
A1
Abstract:
Provided is an isolated antigen-binding protein, which comprises at least one CDR in an antibody heavy chain variable region VH, wherein the VH comprises the amino acid sequence as shown in SEQ ID NO: 39. The isolated antigen-binding protein can specifically bind to streptococcus pneumoniae hemolysin protein and a variant thereof. Further provided is the use of the isolated antigen-binding protein in the prevention and/or treatment of diseases and/or conditions of a streptococcus pneumoniae infection.
Inventors:
AN MAOMAO (CN)
GUO SHIYU (CN)
CHEN SIMIN (CN)
QIU XIRAN (CN)
LI BOHUA (CN)
GUO SHIYU (CN)
CHEN SIMIN (CN)
QIU XIRAN (CN)
LI BOHUA (CN)
Application Number:
PCT/CN2022/082011
Publication Date:
September 29, 2022
Filing Date:
March 21, 2022
Export Citation:
Assignee:
STARMAB BIOLOGICS SUZHOU CO LTD (CN)
STARSHINING BIOLOGICS SHANGHAI CO LTD (CN)
STARSHINING BIOLOGICS SHANGHAI CO LTD (CN)
International Classes:
C07K16/12; A61K39/40; A61P31/04; C12N15/13; G01N33/68
Domestic Patent References:
| WO2012064865A1 | 2012-05-18 | |||
| WO2006030220A1 | 2006-03-23 | |||
| WO2006003388A2 | 2006-01-12 | |||
| WO2015036583A2 | 2015-03-19 |
Foreign References:
| CN101061139A | 2007-10-24 | |||
| CN110167960A | 2019-08-23 | |||
| CN101018863A | 2007-08-15 | |||
| ES2075803A1 | 1995-10-01 | |||
| US6150584A | 2000-11-21 | |||
| US6458592B1 | 2002-10-01 | |||
| US6420140B1 | 2002-07-16 |
Other References:
YAO RUN, CUI YA-LI, YUAN JUN, WANG HONG, GONG YI, YIN YI-BING, ZHANG XUE-MEI: "Protective Effect of Mucosal Immunization with ΔA146Ply against Streptococcus pneumoniae", CHINESE JOURNAL OF BIOLOGICALS, CHINESE PREVENTIVE MEDICINE ASSOCIATION, CHINA, vol. 24, no. 5, 31 May 2011 (2011-05-31), China , pages 579 - 582, XP055970739, ISSN: 1004-5503, DOI: 10.13200/j.cjb.2011.05.88.yaor.007
KUCINSKAITE-KODZE INDRE, SIMANAVICIUS MARTYNAS, DAPKUNAS JUSTAS, PLECKAITYTE MILDA, ZVIRBLIENE AURELIJA: "Mapping of Recognition Sites of Monoclonal Antibodies Responsible for the Inhibition of Pneumolysin Functional Activity", BIOMOLECULES, vol. 10, no. 7, 8 July 2020 (2020-07-08), pages 1009, XP055970747, DOI: 10.3390/biom10071009
DE LOS TOYOS, J. R. ET AL.: "Functional Analysis of Pneumolysin by Use of Monoclonal Antibodies", INFECTION AND IMMUNITY, vol. 64, no. 2, 29 February 1996 (1996-02-29), XP002366575
KORNDORFER, PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS, vol. 53, no. 1, 2003, pages 121 - 129
ROQUE, BIOTECHNOL. PROG., vol. 20, 2004, pages 639 - 654
HAMERS-CASTERMAN, NATURE, vol. 363, 1993, pages 446 - 448
SHERIFF, NATURE STRUCT. BIOL., vol. 3, 1996, pages 733 - 736
LEFRANC, NUCLEIC ACIDS RES., vol. 27, 1999, pages 209 - 212
RUIZ, NUCLEIC ACIDS RES., vol. 28, 2000, pages 219 - 221
LEFRANC, NUCLEIC ACIDS RES., vol. 29, 2001, pages 207 - 209
LEFRANC, NUCLEIC ACIDS RES., vol. 31, 2003, pages 307 - 310
LEFRANC, DEVCOMP IMMUNOL, vol. 29, 2005, pages 185 - 203
KABAT EAWU TT, ANN NY ACADSCI, vol. 190, 1971, pages 382 - 391
KABAT EA: "Sequences of Proteins of Immunological Interest, FifthEdition, U.S. Department of Health and Human Services", 1991, NATIONAL INSTITUTE OF HEALTH, pages: 91 - 3242
"Basic and Clinical Immunology", 1994, APPLETON & LANGE, pages: 71
WARD, NATURE, vol. 341, no. 6242, 12 October 1989 (1989-10-12), pages 544 - 6
HOLT, TRENDS BIOTECHNOL, vol. 21, no. 11, 2003, pages 484 - 490
W.R. PEARSOND.J. LIPMAN: "Improved Tool for Biological Sequence Comparison", PROC. SATL. ACAD. SCI., vol. 85, 1988, pages 2444 - 2448
D.J. LIPMANW.R. PEARSON: "Rapid and Sensitive Protein Similarity Search", SCIENCE, vol. 227, 1989, pages 1435 - 1441
S. ALTSCHULW. GISHW. MILLERE.W. MYERSD. LIPMAN: "A Basic Local Alignment Search Tool", JOURNAL OF MOLECULAR BIOLOGY, vol. 215, 1990, pages 403 - 410
BRUMMELL, BIOCHEM, vol. 32, 1993, pages 1180 - 8
WILDT, PROT. ENG., vol. 10, 1997, pages 835 - 41
KOMISAROV, J. BIOL. CHEM., vol. 272, 1997, pages 26864 - 26870
HALL, J. IMMUNOL., vol. 149, 1992, pages 1605 - 12
KELLEYO'CONNELL, BIOCHEM., vol. 32, 1993, pages 6862 - 35
ADIB CONQUY, INT. IMMUNOL., vol. 10, 1998, pages 341 - 6
BEERS, CLIN. CAN. RES., vol. 6, 2000, pages 2835 - 43
KUCINSKAITE-KODZE INDRE, SIMANAVICIUS MARTYNAS, DAPKUNAS JUSTAS, PLECKAITYTE MILDA, ZVIRBLIENE AURELIJA: "Mapping of Recognition Sites of Monoclonal Antibodies Responsible for the Inhibition of Pneumolysin Functional Activity", BIOMOLECULES, vol. 10, no. 7, 8 July 2020 (2020-07-08), pages 1009, XP055970747, DOI: 10.3390/biom10071009
DE LOS TOYOS, J. R. ET AL.: "Functional Analysis of Pneumolysin by Use of Monoclonal Antibodies", INFECTION AND IMMUNITY, vol. 64, no. 2, 29 February 1996 (1996-02-29), XP002366575
KORNDORFER, PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS, vol. 53, no. 1, 2003, pages 121 - 129
ROQUE, BIOTECHNOL. PROG., vol. 20, 2004, pages 639 - 654
HAMERS-CASTERMAN, NATURE, vol. 363, 1993, pages 446 - 448
SHERIFF, NATURE STRUCT. BIOL., vol. 3, 1996, pages 733 - 736
LEFRANC, NUCLEIC ACIDS RES., vol. 27, 1999, pages 209 - 212
RUIZ, NUCLEIC ACIDS RES., vol. 28, 2000, pages 219 - 221
LEFRANC, NUCLEIC ACIDS RES., vol. 29, 2001, pages 207 - 209
LEFRANC, NUCLEIC ACIDS RES., vol. 31, 2003, pages 307 - 310
LEFRANC, DEVCOMP IMMUNOL, vol. 29, 2005, pages 185 - 203
KABAT EAWU TT, ANN NY ACADSCI, vol. 190, 1971, pages 382 - 391
KABAT EA: "Sequences of Proteins of Immunological Interest, FifthEdition, U.S. Department of Health and Human Services", 1991, NATIONAL INSTITUTE OF HEALTH, pages: 91 - 3242
"Basic and Clinical Immunology", 1994, APPLETON & LANGE, pages: 71
WARD, NATURE, vol. 341, no. 6242, 12 October 1989 (1989-10-12), pages 544 - 6
HOLT, TRENDS BIOTECHNOL, vol. 21, no. 11, 2003, pages 484 - 490
W.R. PEARSOND.J. LIPMAN: "Improved Tool for Biological Sequence Comparison", PROC. SATL. ACAD. SCI., vol. 85, 1988, pages 2444 - 2448
D.J. LIPMANW.R. PEARSON: "Rapid and Sensitive Protein Similarity Search", SCIENCE, vol. 227, 1989, pages 1435 - 1441
S. ALTSCHULW. GISHW. MILLERE.W. MYERSD. LIPMAN: "A Basic Local Alignment Search Tool", JOURNAL OF MOLECULAR BIOLOGY, vol. 215, 1990, pages 403 - 410
BRUMMELL, BIOCHEM, vol. 32, 1993, pages 1180 - 8
WILDT, PROT. ENG., vol. 10, 1997, pages 835 - 41
KOMISAROV, J. BIOL. CHEM., vol. 272, 1997, pages 26864 - 26870
HALL, J. IMMUNOL., vol. 149, 1992, pages 1605 - 12
KELLEYO'CONNELL, BIOCHEM., vol. 32, 1993, pages 6862 - 35
ADIB CONQUY, INT. IMMUNOL., vol. 10, 1998, pages 341 - 6
BEERS, CLIN. CAN. RES., vol. 6, 2000, pages 2835 - 43
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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