Title:
ANTIGEN COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2019/031446
Kind Code:
A1
Abstract:
[Problem] To provide a method and a composition for enhancing the immunogenicity of a polypeptide.
[Solution] Provided is a composition containing a tagged polypeptide which is composed of a polypeptide, a spacer peptide bonded to a terminal of the polypeptide and composed of 0 to 2 amino acid residues, and a tag peptide bonded to the spacer peptide and composed of 3 to 12 amino acid residues, wherein the tag peptide is composed of Ile, Val, Lys, Arg, Asn, Asp, Ser, Leu, Ala, His, Pro or a combination thereof.
Inventors:
KURODA YUTAKA (JP)
KAMIOKA TETSUYA (JP)
RAHMAN NAFSOON (JP)
ISLAM MONIRUL MOHAMMAD (JP)
MIURA SHIHO (JP)
KAMIOKA TETSUYA (JP)
RAHMAN NAFSOON (JP)
ISLAM MONIRUL MOHAMMAD (JP)
MIURA SHIHO (JP)
Application Number:
PCT/JP2018/029395
Publication Date:
February 14, 2019
Filing Date:
August 06, 2018
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY (JP)
International Classes:
C07K2/00; A61K39/12; A61K39/39; A61P31/14; C07K14/18
Foreign References:
JP5273438B2 | 2013-08-28 | |||
JP2006188507A | 2006-07-20 | |||
US20140046035A1 | 2014-02-13 |
Other References:
ISLAM, M. DHALI. ET AL.: "Short solubility controlling peptide tags to control immune responses", THE GENERAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, vol. 113, 2013, pages 1440
KATO, JUN ET AL.: "Methods for Enhancing Protein Solubility and the Effect of SEP-Tags on Protein Solubility", SEIBUTSU BUTSURI, BIOPHYSICS,, vol. 48, no. 3, 2008, pages 185 - 187, XP055096852, DOI: 10.2142/biophys.48.185
JOZAWA HIROKI . ET AL.: "Amorphous protein aggregation monitored using fluorescence self-quenching", FEBS LETTERS, vol. 590, no. 20, 1 October 2016 (2016-10-01), pages 3501 - 3509, XP055575333
KULKARNI MANJIRI R. ET AL.: "Modeling and expeimental assessment of a buried Leu-Ile mutation in dengue envelope domain III", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 471, 2016, pages 163 - 168, XP029430817, DOI: doi:10.1016/j.bbrc.2016.01.159
KATO, JUN ET AL.: "Methods for Enhancing Protein Solubility and the Effect of SEP-Tags on Protein Solubility", SEIBUTSU BUTSURI, BIOPHYSICS,, vol. 48, no. 3, 2008, pages 185 - 187, XP055096852, DOI: 10.2142/biophys.48.185
JOZAWA HIROKI . ET AL.: "Amorphous protein aggregation monitored using fluorescence self-quenching", FEBS LETTERS, vol. 590, no. 20, 1 October 2016 (2016-10-01), pages 3501 - 3509, XP055575333
KULKARNI MANJIRI R. ET AL.: "Modeling and expeimental assessment of a buried Leu-Ile mutation in dengue envelope domain III", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 471, 2016, pages 163 - 168, XP029430817, DOI: doi:10.1016/j.bbrc.2016.01.159
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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