Title:
ANTIGEN POLYPEPTIDE, CODING GENE THEREOF, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/006599
Kind Code:
A1
Abstract:
Provided are an HPV16 E7 40-74 antigen polypeptide, a coding gene of the antigen polypeptide, an expression vector for expressing the antigen polypeptide, and a host cell containing the expression vector. Also provided are uses of the coding gene of the antigen polypeptide, the expression vector and the host cell in the preparation of vaccines for preventing or treating tumor diseases such as cervical cancer. Further provided are an antibody prepared by using the antigen polypeptide and the uses of the antibody in the preparation of drugs for preventing or treating tumor diseases such as cervical cancer.
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Inventors:
ZHANG LONG (CN)
WU YANHENG (CN)
GU WENYI (CN)
XU ZHIPING (CN)
WU YANHENG (CN)
GU WENYI (CN)
XU ZHIPING (CN)
Application Number:
PCT/CN2017/091528
Publication Date:
January 10, 2019
Filing Date:
July 03, 2017
Export Citation:
Assignee:
GUANGZHOU MACRO SOURCE BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K14/025; A61K39/00; A61K39/395; A61P35/00; C07K16/08; C12N15/37
Domestic Patent References:
| WO2002070006A2 | 2002-09-12 |
Other References:
SJOERD H. VAN DER BURG.: "Natural T-HELPER immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16- positive cervical lesions: Identification of 3 human leukocyte antigen class II-restricted epitopes", INTERNATIONAL JOURNAL OF CANCER, vol. 91, no. 5, 1 March 2001 (2001-03-01), pages 612 - 618, XP001027084, ISSN: 0020-7136, DOI: 10.1002/1097-0215(200002)9999:9999<::AID-IJC1119>3.0.CO;2-C
SANDER ZWAVELING: "Established human papillomavirus type 16-expressing tu- mors are effectively eradicated following vaccination with long peptides", THE JOURNAL OF IMMUNOLOGY, vol. 169, no. 1, 1 July 2002 (2002-07-01), pages 350 - 358, XP002452052, ISSN: 0022-1767, DOI: 10.4049/jimmunol.169.1.350
DARJA KANDUC.: "Individuation of monoclonal anti-HPV16 E7 antibody linear peptide epitope by computational biology", PEPTIDES, vol. 22, no. 12, 31 December 2001 (2001-12-31), pages 1981 - 1985, XP055678313, ISSN: 0196-9781, DOI: 10.1016/S0196-9781(01)00539-3
DARJA KANDUC: "NMR probing of in silico identification of anti-HPV16 E7 mAb linear peptide epitope", PEPTIDES, vol. 25, no. 2, 29 February 2004 (2004-02-29), pages 243 - 250, XP055678316, ISSN: 0196-9781, DOI: 10.1016/j.peptides.2003.12.004
AZAM BOLHASSANI: "Different spectra of therapeutic vaccine development against HPV infections", HUMAN VACCINES, vol. 5, no. 10, 1 October 2009 (2009-10-01), pages 671 - 689, XP055678320, ISSN: 1554-8619, DOI: 10.4161/hv.5.10.9370
SANDER ZWAVELING: "Established human papillomavirus type 16-expressing tu- mors are effectively eradicated following vaccination with long peptides", THE JOURNAL OF IMMUNOLOGY, vol. 169, no. 1, 1 July 2002 (2002-07-01), pages 350 - 358, XP002452052, ISSN: 0022-1767, DOI: 10.4049/jimmunol.169.1.350
DARJA KANDUC.: "Individuation of monoclonal anti-HPV16 E7 antibody linear peptide epitope by computational biology", PEPTIDES, vol. 22, no. 12, 31 December 2001 (2001-12-31), pages 1981 - 1985, XP055678313, ISSN: 0196-9781, DOI: 10.1016/S0196-9781(01)00539-3
DARJA KANDUC: "NMR probing of in silico identification of anti-HPV16 E7 mAb linear peptide epitope", PEPTIDES, vol. 25, no. 2, 29 February 2004 (2004-02-29), pages 243 - 250, XP055678316, ISSN: 0196-9781, DOI: 10.1016/j.peptides.2003.12.004
AZAM BOLHASSANI: "Different spectra of therapeutic vaccine development against HPV infections", HUMAN VACCINES, vol. 5, no. 10, 1 October 2009 (2009-10-01), pages 671 - 689, XP055678320, ISSN: 1554-8619, DOI: 10.4161/hv.5.10.9370
Attorney, Agent or Firm:
SCIHEAD IP LAW FIRM (CN)
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