Title:
ANTIGEN-SPECIFIC T CELL RECEPTORS AND CHIMERIC ANTIGEN RECEPTORS, AND METHODS OF USE IN IMMUNE SIGNALING MODULATION FOR CANCER IMMUNOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2021/263211
Kind Code:
A3
Abstract:
The present invention relates to T cell receptors (TCR) against cancer/testis antigens NY-ESO-1 and CT83 presented by multiple HLA molecules. The preferred TCRs of the invention deriving from human T cells demonstrates high affinity and antigen specificity in vitro and in vivo. The present invention also relates to the modulation of TCR-T CAR-T cell signaling and functional persistence in cancer immunotherapy.
Inventors:
WANG RONGFU (US)
WANG YICHENG (US)
YIN BINGNAN (US)
QIAN CHEN (US)
LIU XIN (US)
WANG YICHENG (US)
YIN BINGNAN (US)
QIAN CHEN (US)
LIU XIN (US)
Application Number:
PCT/US2021/039262
Publication Date:
March 10, 2022
Filing Date:
June 25, 2021
Export Citation:
Assignee:
HOUSTON METHODIST HOSPITAL (US)
International Classes:
A61K35/17; A61P35/00; C07K14/725; C12N15/86
Domestic Patent References:
| WO2020086647A1 | 2020-04-30 | |||
| WO2017044672A1 | 2017-03-16 | |||
| WO2014118236A2 | 2014-08-07 |
Foreign References:
| US20190085081A1 | 2019-03-21 | |||
| US20170290858A1 | 2017-10-12 |
Attorney, Agent or Firm:
NORTON, Vicki G. (US)
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