Title:
ANTIGENIC PEPTIDES FOR THE DIAGNOSIS, THERAPY MONITORING AND/OR TREATMENT OF PSORIASIS VULGARIS
Document Type and Number:
WIPO Patent Application WO/2017/005615
Kind Code:
A3
Abstract:
The present invention relates to peptides with a conserved amino acid motif and pharmaceutical compositions comprising these peptides. The present invention further relates to the use of the peptides as biomarker, the medical use of the peptides, in particular in the diagnosis, prevention, monitoring and/or treatment of Psoriasis. The present invention relates to complexes of the peptides of the invention with HLA-C monomers or multimers and their use as biomarker and their medical uses, in particular in the treatment of Psoriasis and in monitoring such treatment. The present invention furthermore relates to means and methods for the prevention and/or treatment of Psoriasis, that comprise inhibiting or blocking the interaction of TCR and HLA-C.
Inventors:
PRINZ JÖRG CHRISTOPH (DE)
DORNMAIR KLAUS (DE)
DORNMAIR KLAUS (DE)
Application Number:
PCT/EP2016/065416
Publication Date:
July 13, 2017
Filing Date:
June 30, 2016
Export Citation:
Assignee:
UNIV MUENCHEN LUDWIG MAXIMILIANS (DE)
International Classes:
C07K7/06; C07K14/47; C07K14/74; G01N33/50; G01N33/564; G01N33/569
Domestic Patent References:
| WO2000043511A1 | 2000-07-27 | |||
| WO2012017081A1 | 2012-02-09 | |||
| WO2009103312A1 | 2009-08-27 | |||
| WO2013104804A2 | 2013-07-18 | |||
| WO2008118017A2 | 2008-10-02 |
Foreign References:
| US20080025951A1 | 2008-01-31 |
Other References:
GNJATIC SACHA ET AL: "Strategy for monitoring T cell responses to NY-ESO-1 in patients with any HLA class I allele", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 97, no. 20, 29 September 2000 (2000-09-29), pages 10917 - 10922, XP002197704, ISSN: 0027-8424, DOI: 10.1073/PNAS.97.20.10917
STEITZ J ET AL: "Initiation and regulation of CD8+T cells recognizing melanocytic antigens in the epidermis: Implications for the pathophysiology of vitiligo", EUROPEAN JOURNAL OF CELL BIOLOGY, WISSENSCHAFLICHE VERLAGSGESELLSCHAFT, STUTTGART, DE, vol. 83, no. 11-12, 1 January 2004 (2004-01-01), pages 797 - 803, XP004954730, ISSN: 0171-9335, DOI: 10.1078/0171-9335-00423
MARGET M ET AL: "A HLA-Cw6 specific single-chain antibody fragment (scFv) recognizing a natural killer cell receptor epitope", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 42, no. 5, 1 March 2005 (2005-03-01), pages 643 - 649, XP027634927, ISSN: 0161-5890, [retrieved on 20050301]
M. TALAMONTI ET AL: "Pharmacogenetics of psoriasis: HLA-Cw6 but not LCE3B/3C deletion nor TNFAIP3 polymorphism predisposes to clinical response to interleukin 12/23 blocker ustekinumab", BRITISH JOURNAL OF DERMATOLOGY, vol. 169, no. 2, 13 August 2013 (2013-08-13), UK, pages 458 - 463, XP055218908, ISSN: 0007-0963, DOI: 10.1111/bjd.12331
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1 July 1998 (1998-07-01), SMITH ROBERT E ET AL: "The significance of hypersialyation of dipeptidyl peptidase IV (CD26) in the inhibition of its activity by Tat and other cationic peptides. CD26: A subverted adhesion molecule for HIV peptide binding", XP002760816, Database accession no. PREV199800362787
STEITZ J ET AL: "Initiation and regulation of CD8+T cells recognizing melanocytic antigens in the epidermis: Implications for the pathophysiology of vitiligo", EUROPEAN JOURNAL OF CELL BIOLOGY, WISSENSCHAFLICHE VERLAGSGESELLSCHAFT, STUTTGART, DE, vol. 83, no. 11-12, 1 January 2004 (2004-01-01), pages 797 - 803, XP004954730, ISSN: 0171-9335, DOI: 10.1078/0171-9335-00423
MARGET M ET AL: "A HLA-Cw6 specific single-chain antibody fragment (scFv) recognizing a natural killer cell receptor epitope", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 42, no. 5, 1 March 2005 (2005-03-01), pages 643 - 649, XP027634927, ISSN: 0161-5890, [retrieved on 20050301]
M. TALAMONTI ET AL: "Pharmacogenetics of psoriasis: HLA-Cw6 but not LCE3B/3C deletion nor TNFAIP3 polymorphism predisposes to clinical response to interleukin 12/23 blocker ustekinumab", BRITISH JOURNAL OF DERMATOLOGY, vol. 169, no. 2, 13 August 2013 (2013-08-13), UK, pages 458 - 463, XP055218908, ISSN: 0007-0963, DOI: 10.1111/bjd.12331
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1 July 1998 (1998-07-01), SMITH ROBERT E ET AL: "The significance of hypersialyation of dipeptidyl peptidase IV (CD26) in the inhibition of its activity by Tat and other cationic peptides. CD26: A subverted adhesion molecule for HIV peptide binding", XP002760816, Database accession no. PREV199800362787
Attorney, Agent or Firm:
BOEHMERT & BOEHMERT ANWALTSPARTNERSCHAFT MBB (DE)
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