Title:
ANTIHUMAN CCR7 ANTIBODIES, HYBRIDOMA, NUCLEIC ACID, VECTOR, CELL, MEDICINAL COMPOSITION, AND ANTIBODY-IMMOBILIZED CARRIER
Document Type and Number:
WIPO Patent Application WO/2012/043533
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel antihuman CCR7 antibody which is useful as a therapeutic agent for tissue fibrosis or cancer, a medicinal composition which comprises the antihuman CCR7 antibody, and so on. Provided is an antihuman CCR7 antibody binding specifically to the extracellular domain of human CCR7, said antihuman CCR7 antibody having a heavy chain CDR3 which comprises an amino acid sequence represented by SEQ ID NO: 7, 17, 27, 37, 47, 57, 67 or 77. Also provided is an antihuman CCR7 antibody which has heavy chain CDRs 1-3 and light chain CDRs 1-3, said heavy chain CDRs 1-3 and light chain CDRs 1-3 respectively comprising amino acid sequences represented by SEQ ID NOS:5-10, 15-20, 25-30, 35-40, 45-50, 55-60, 65-70 or 75-80. Preferably, such an antihuman CCR7 antibody has an activity of blocking CCR7-dependent intracellular signal transduction mechanism that is induced by stimulation with CCR7 ligands. The antihuman CCR7 antibodies according to the present invention are usable as the active ingredient of a therapeutic agent for tissue fibrosis or cancer.
Inventors:
NISHIGUCHI NAOKI (JP)
YOON MYUNG-EUI (JP)
FURUTANI MASAHIRO (JP)
SHIMIZU TATSUO (JP)
TAKAYAMA KIYOSHI (JP)
SHIMIZU TOMOKO (JP)
SUZUKI KAZUYA (JP)
YOON MYUNG-EUI (JP)
FURUTANI MASAHIRO (JP)
SHIMIZU TATSUO (JP)
TAKAYAMA KIYOSHI (JP)
SHIMIZU TOMOKO (JP)
SUZUKI KAZUYA (JP)
Application Number:
PCT/JP2011/072014
Publication Date:
April 05, 2012
Filing Date:
September 27, 2011
Export Citation:
Assignee:
SEKISUI CHEMICAL CO LTD (JP)
NB HEALTH LAB CO LTD (JP)
NISHIGUCHI NAOKI (JP)
YOON MYUNG-EUI (JP)
FURUTANI MASAHIRO (JP)
SHIMIZU TATSUO (JP)
TAKAYAMA KIYOSHI (JP)
SHIMIZU TOMOKO (JP)
SUZUKI KAZUYA (JP)
NB HEALTH LAB CO LTD (JP)
NISHIGUCHI NAOKI (JP)
YOON MYUNG-EUI (JP)
FURUTANI MASAHIRO (JP)
SHIMIZU TATSUO (JP)
TAKAYAMA KIYOSHI (JP)
SHIMIZU TOMOKO (JP)
SUZUKI KAZUYA (JP)
International Classes:
A61K31/713; C12N15/09; A61K39/395; A61P1/04; A61P1/16; A61P3/10; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P29/00; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C07K16/28; C07K16/46; C07K17/02; C12N5/10
Domestic Patent References:
| WO2004104574A2 | 2004-12-02 | |||
| WO2008020586A1 | 2008-02-21 | |||
| WO2008072723A1 | 2008-06-19 | |||
| WO2007146172A2 | 2007-12-21 | |||
| WO1996022373A2 | 1996-07-25 | |||
| WO1993011161A1 | 1993-06-10 | |||
| WO2006041157A1 | 2006-04-20 | |||
| WO1993017706A1 | 1993-09-16 |
Foreign References:
| JP2008545000A | 2008-12-11 | |||
| JP2003028858A | 2003-01-29 | |||
| JP2009528977A | 2009-08-13 | |||
| JP2009528977A | 2009-08-13 | |||
| US3773919A | 1973-11-20 | |||
| EP0058481A1 | 1982-08-25 | |||
| EP0133988A2 | 1985-03-13 | |||
| US4945050A | 1990-07-31 |
Other References:
ALFONSO-PEREZ MANUEL ET AL.: "Anti-CCR7 monoclonal antibodies as a novel tool for the treatment of chronic lymphocyte leukemia", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 79, 2006, pages 1157 - 1165, XP009073183
CAMPBELL J. JAMES ET AL.: "CCR7 Expression and Memory T Cell Diversity in Humans", JOURNAL OF IMMUNOLOGY, vol. 166, 2001, pages 877 - 884, XP008162963
BIRKENBACH MARK ET AL.: "Epstein-Barr Virus- Induced Genes: First Lymphocyte-specific G Protein-Coupled Peptide Receptors", JOURNAL OF VIROLOGY, vol. 67, no. 4, 1993, pages 2209 - 2220, XP002061884
SCHWEICKART L. VICKI ET AL.: "Cloning of Human and Mouse EBI1, a Lymphoid-Specific G-Protein- Coupled Receptor Encoded on Human Chromosome 17q12-q21.2", GENOMICS, vol. 23, 1994, pages 643 - 650, XP024796762
VIOLA A; LUSTER AD: "Chemokines and their receptors: drug targets in immunity and inflammation", ANNU REV PHARMACOL TOXICOL., vol. 48, 2008, pages 171 - 97, XP002579388, DOI: doi:10.1147/annurev.pharmtox.48.121806.154841
BIRKENBACH, M.; JOSEFSEN, K.; YALAMANCHILI, R.; LENOIR, G.; KIEFF, E.: "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors", J. VIROL., vol. 67, 1993, pages 2209 - 2220, XP002061884
PILLING D; FAN T; HUANG D; KAUL B; GOMER RH: "Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts", PLOS ONE, vol. 4, no. 10, 16 October 2009 (2009-10-16), pages E7475
WADA T; SAKAI N; MATSUSHIMA K; KANEKO S: "Fibrocytes: a new insight into kidney fibrosis", KIDNEY INT., vol. 72, no. 3, August 2007 (2007-08-01), pages 269 - 73, XP009149767
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
"Remingto's Pharmaceutical Science", 1980
LANGER ET AL., J. BIOMED. MASTER. RES., vol. 15, 1981, pages 167 - 277
LANGER, CHEM. TECH., vol. 12, 1982, pages 98 - 105
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
ADOLPH: "Viral Genomic Methods", 1996, CRC PRESS
ABE R; DONNELLY SC; PENG T; BUCALA R; METZ CN: "Peripheral blood fibrocytes: differentiation pathway and migration to wound sites", J IMMUNOL., vol. 166, no. 12, 15 June 2001 (2001-06-15), pages 7556 - 62, XP002958725
CURNOW SJ; FAIRCLOUGH M; SCHMUTZ C; KISSANE S; DENNISTONAK; NASH K; BUCKLEY CD; LORD JM; SALMON M: "Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum", PLOS ONE, vol. 5, no. 3, 18 March 2010 (2010-03-18), pages E9730
See also references of EP 2623592A4
CAMPBELL J. JAMES ET AL.: "CCR7 Expression and Memory T Cell Diversity in Humans", JOURNAL OF IMMUNOLOGY, vol. 166, 2001, pages 877 - 884, XP008162963
BIRKENBACH MARK ET AL.: "Epstein-Barr Virus- Induced Genes: First Lymphocyte-specific G Protein-Coupled Peptide Receptors", JOURNAL OF VIROLOGY, vol. 67, no. 4, 1993, pages 2209 - 2220, XP002061884
SCHWEICKART L. VICKI ET AL.: "Cloning of Human and Mouse EBI1, a Lymphoid-Specific G-Protein- Coupled Receptor Encoded on Human Chromosome 17q12-q21.2", GENOMICS, vol. 23, 1994, pages 643 - 650, XP024796762
VIOLA A; LUSTER AD: "Chemokines and their receptors: drug targets in immunity and inflammation", ANNU REV PHARMACOL TOXICOL., vol. 48, 2008, pages 171 - 97, XP002579388, DOI: doi:10.1147/annurev.pharmtox.48.121806.154841
BIRKENBACH, M.; JOSEFSEN, K.; YALAMANCHILI, R.; LENOIR, G.; KIEFF, E.: "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors", J. VIROL., vol. 67, 1993, pages 2209 - 2220, XP002061884
PILLING D; FAN T; HUANG D; KAUL B; GOMER RH: "Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts", PLOS ONE, vol. 4, no. 10, 16 October 2009 (2009-10-16), pages E7475
WADA T; SAKAI N; MATSUSHIMA K; KANEKO S: "Fibrocytes: a new insight into kidney fibrosis", KIDNEY INT., vol. 72, no. 3, August 2007 (2007-08-01), pages 269 - 73, XP009149767
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
"Remingto's Pharmaceutical Science", 1980
LANGER ET AL., J. BIOMED. MASTER. RES., vol. 15, 1981, pages 167 - 277
LANGER, CHEM. TECH., vol. 12, 1982, pages 98 - 105
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
ADOLPH: "Viral Genomic Methods", 1996, CRC PRESS
ABE R; DONNELLY SC; PENG T; BUCALA R; METZ CN: "Peripheral blood fibrocytes: differentiation pathway and migration to wound sites", J IMMUNOL., vol. 166, no. 12, 15 June 2001 (2001-06-15), pages 7556 - 62, XP002958725
CURNOW SJ; FAIRCLOUGH M; SCHMUTZ C; KISSANE S; DENNISTONAK; NASH K; BUCKLEY CD; LORD JM; SALMON M: "Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum", PLOS ONE, vol. 5, no. 3, 18 March 2010 (2010-03-18), pages E9730
See also references of EP 2623592A4
Attorney, Agent or Firm:
FUJITA Takashi et al. (JP)
Takashi Fujita (JP)
Takashi Fujita (JP)
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