Title:
ANTIHUMAN PRE-B CELL RECEPTOR ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/1999/006541
Kind Code:
A1
Abstract:
An antibody recognizing a human pre-B cell receptor but not a human pro-B cell; an antibody reacting with a V pre-B molecule which is one of the constituents of the SL chain of a human pre-B cellreceptor expressed on the surface of the membrane of a human pre-B cell or with a V pre-B cell expressed in a human pro-B cell, but not with a $g(l)5 molecule in a replacing light chain and showing a reactivity to such an extent that the human pre-B cell or human pro-B cell thus reacted with the antibody can be detected under a microscope; and a method for judging the B-cell differentiation step causative of acute lymphatic leukemia of infant by using the antibody recognizing a human pre-B cell receptor but not a human pro-B cell, an antibody recognizing a V pre-B molecule in a replacing light chain consitituting a human pre-B cell receptor, an antibody recognizing a $g(l)5 molecule in a replacing light chain constituting a human pre-B cell receptor, and an antibody recognizing a B cell.
Inventors:
TSUGANEZAWA KEIKO (JP)
KARASUYAMA HAJIME (JP)
KARASUYAMA HAJIME (JP)
Application Number:
PCT/JP1998/003384
Publication Date:
February 11, 1999
Filing Date:
July 29, 1998
Export Citation:
Assignee:
SUMITOMO ELECTRIC INDUSTRIES (JP)
TSUGANEZAWA KEIKO (JP)
KARASUYAMA HAJIME (JP)
TSUGANEZAWA KEIKO (JP)
KARASUYAMA HAJIME (JP)
International Classes:
C07K16/28; C12P21/08; G01N33/569; (IPC1-7): C12N15/02; C07K16/28; C12N5/12; C12P21/08; G01N33/53; G01N33/537
Other References:
LASSOUED K, ET AL.: "EXPRESSION OF SURROGATE LIGHT CHAIN RECEPTORS IS RESTRICTED TO A LATE STAGE IN PRE-B CELL DIFFERENTIATION", CELL, CELL PRESS, US, vol. 73, no. 01, 9 September 1993 (1993-09-09), US, pages 73 - 86, XP002920267, ISSN: 0092-8674, DOI: 10.1016/0092-8674(93)90161-I
SANZ E, HERA DE LA A: "A NOVEL ANTI-VPRE-B ANTIBODY IDENTIFIES IMMUNOGLOBULIN-SURROGATE RECEPTORS ON THE SURFACE OF HUMAN PRO-B CELLS", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 183, no. 06, 1 January 1996 (1996-01-01), US, pages 2693 - 2698, XP002920268, ISSN: 0022-1007, DOI: 10.1084/jem.183.6.2693
GUELPA-FONLUPT V, ET AL.: "DISCRETE EARLY PRO-B AND PRE-B STAGES IN NORMAL HUMAN BONE MARROW AS DEFINED BY SURFACE PSEUDO-LIGHT CHAIN EXPRESSION", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 24, no. 04, 1 January 1994 (1994-01-01), DE, pages 257 - 264, XP002920269, ISSN: 0014-2980, DOI: 10.1002/eji.1830240140
MEFFRE E, ET AL.: "CELL SURFACE EXPRESSION OF SURROGATE LIGHT CHAIN (PSIL) IN THE ABSENCE OF MU ON HUMAN PRO-B CELL LINES AND NORMAL PRO-B CELLS", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 26, no. 09, 1 January 1996 (1996-01-01), DE, pages 2172 - 2180, XP002920270, ISSN: 0014-2980, DOI: 10.1002/eji.1830260932
See also references of EP 1001020A4
SANZ E, HERA DE LA A: "A NOVEL ANTI-VPRE-B ANTIBODY IDENTIFIES IMMUNOGLOBULIN-SURROGATE RECEPTORS ON THE SURFACE OF HUMAN PRO-B CELLS", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 183, no. 06, 1 January 1996 (1996-01-01), US, pages 2693 - 2698, XP002920268, ISSN: 0022-1007, DOI: 10.1084/jem.183.6.2693
GUELPA-FONLUPT V, ET AL.: "DISCRETE EARLY PRO-B AND PRE-B STAGES IN NORMAL HUMAN BONE MARROW AS DEFINED BY SURFACE PSEUDO-LIGHT CHAIN EXPRESSION", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 24, no. 04, 1 January 1994 (1994-01-01), DE, pages 257 - 264, XP002920269, ISSN: 0014-2980, DOI: 10.1002/eji.1830240140
MEFFRE E, ET AL.: "CELL SURFACE EXPRESSION OF SURROGATE LIGHT CHAIN (PSIL) IN THE ABSENCE OF MU ON HUMAN PRO-B CELL LINES AND NORMAL PRO-B CELLS", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 26, no. 09, 1 January 1996 (1996-01-01), DE, pages 2172 - 2180, XP002920270, ISSN: 0014-2980, DOI: 10.1002/eji.1830260932
See also references of EP 1001020A4
Attorney, Agent or Firm:
Hasegawa, Yoshiki (Kyobashi National Building 13-10, Kyobashi 2-chome Chuo-ku Tokyo, JP)
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